Molecular genetic framework underlying pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare, progressive disorder typified by occlusion
of the pulmonary arterioles owing to endothelial dysfunction and uncontrolled proliferation of …
of the pulmonary arterioles owing to endothelial dysfunction and uncontrolled proliferation of …
Definitions and diagnosis of pulmonary hypertension
MM Hoeper, HJ Bogaard, R Condliffe, R Frantz… - Journal of the American …, 2013 - jacc.org
Pulmonary hypertension (PH) is defined by a mean pulmonary artery pressure≥ 25 mm Hg
at rest, measured during right heart catheterization. There is still insufficient evidence to add …
at rest, measured during right heart catheterization. There is still insufficient evidence to add …
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension
Genetic evidence implicates the loss of bone morphogenetic protein type II receptor (BMPR-
II) signaling in the endothelium as an initiating factor in pulmonary arterial hypertension …
II) signaling in the endothelium as an initiating factor in pulmonary arterial hypertension …
Management of pulmonary arterial hypertension
Pulmonary hypertension (PH) is common and may result from a number of disorders,
including left heart disease, lung disease, and chronic thromboembolic disease. Pulmonary …
including left heart disease, lung disease, and chronic thromboembolic disease. Pulmonary …
Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era
M Humbert, O Sitbon, A Chaouat, M Bertocchi… - Circulation, 2010 - Am Heart Assoc
Background—Novel therapies have recently become available for pulmonary arterial
hypertension. We conducted a study to characterize mortality in a multicenter prospective …
hypertension. We conducted a study to characterize mortality in a multicenter prospective …
ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation task force on expert consensus …
Writing Committee Members, VV McLaughlin… - Circulation, 2009 - Am Heart Assoc
ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension | Circulation Science
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Updated clinical classification of pulmonary hypertension
G Simonneau, IM Robbins, M Beghetti… - Journal of the American …, 2009 - jacc.org
The aim of a clinical classification of pulmonary hypertension (PH) is to group together
different manifestations of disease sharing similarities in pathophysiologic mechanisms …
different manifestations of disease sharing similarities in pathophysiologic mechanisms …
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension
E Spiekerkoetter, X Tian, J Cai… - The Journal of …, 2013 - Am Soc Clin Investig
Dysfunctional bone morphogenetic protein receptor-2 (BMPR2) signaling is implicated in the
pathogenesis of pulmonary arterial hypertension (PAH). We used a transcriptional high …
pathogenesis of pulmonary arterial hypertension (PAH). We used a transcriptional high …
Cellular and molecular pathobiology of pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) has a multifactorial pathobiology. Vasoconstriction,
remodeling of the pulmonary vessel wall, and thrombosis contribute to increased pulmonary …
remodeling of the pulmonary vessel wall, and thrombosis contribute to increased pulmonary …
Clinical classification of pulmonary hypertension
Abstract In 1998, during the Second World Symposium on Pulmonary Hypertension (PH)
held in Evian, France, a clinical classification of PH was proposed. The aim of the Evian …
held in Evian, France, a clinical classification of PH was proposed. The aim of the Evian …