Convergent evolution of toxin resistance in animals

J van Thiel, MA Khan, RM Wouters, RJ Harris… - Biological …, 2022 - Wiley Online Library
Convergence is the phenomenon whereby similar phenotypes evolve independently in
different lineages. One example is resistance to toxins in animals. Toxins have evolved …

Animal models of exercise from rodents to pythons

MH Hastings, JJ Herrera, JS Guseh, B Atlason… - Circulation …, 2022 - Am Heart Assoc
Acute and chronic animal models of exercise are commonly used in research. Acute
exercise testing is used, often in combination with genetic, pharmacological, or other …

Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards

AL Lind, YYY Lai, Y Mostovoy, AK Holloway… - Nature ecology & …, 2019 - nature.com
Monitor lizards are unique among ectothermic reptiles in that they have high aerobic
capacity and distinctive cardiovascular physiology resembling that of endothermic …

Molecular regulation of reversible cardiac remodeling: lessons from species with extreme physiological adaptations

TG Martin, LA Leinwand - Journal of Experimental Biology, 2024 - journals.biologists.com
Some vertebrates evolved to have a remarkable capacity for anatomical and physiological
plasticity in response to environmental challenges. One example of such plasticity can be …

Postprandial cardiac hypertrophy is sustained by mechanics, epigenetic, and metabolic reprogramming in pythons

C Crocini, KC Woulfe, CD Ozeroff, S Perni… - Proceedings of the …, 2024 - pnas.org
Constricting pythons, known for their ability to consume infrequent, massive meals, exhibit
rapid and reversible cardiac hypertrophy following feeding. Our primary goal was to …

The gut–brain axis in vertebrates: implications for food intake regulation

AM Blanco, J Calo, JL Soengas - Journal of experimental …, 2021 - journals.biologists.com
The gut and brain are constantly communicating and influencing each other through neural,
endocrine and immune signals in an interaction referred to as the gut–brain axis. Within this …

The elusive hypertrophy of the python heart

B Jensen, T Wang - Physiology, 2024 - journals.physiology.org
The Burmese python, one of the world's largest snakes, has reached celebrity status for its
dramatic physiological responses associated with digestion of enormous meals. The meals …

Utility of the burmese Python as a model for studying plasticity of extreme physiological systems

Y Tan, TG Martin, BC Harrison, LA Leinwand - Journal of muscle research …, 2023 - Springer
Non-traditional animal models present an opportunity to discover novel biology that has
evolved to allow such animals to survive in extreme environments. One striking example is …

Reptiles as a model system to study heart development

B Jensen, VM Christoffels - Cold Spring Harbor …, 2020 - cshperspectives.cshlp.org
A chambered heart is common to all vertebrates, but reptiles show unparalleled variation in
ventricular septation, ranging from almost absent in tuataras to full in crocodilians. Because …

Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage

JA Magida, Y Tan, CE Wall, BC Harrison… - Journal of General …, 2022 - rupress.org
As an opportunistic predator, the Burmese python (Python molurus bivittatus) consumes
large and infrequent meals, fasting for up to a year. Upon consuming a large meal, the …