Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics
T Nojima, NJ Proudfoot - Nature reviews Molecular cell biology, 2022 - nature.com
Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …
mediated transcription: protein-coding transcription units and non-coding RNA transcription …
The functions and unique features of long intergenic non-coding RNA
JD Ransohoff, Y Wei, PA Khavari - Nature reviews Molecular cell …, 2018 - nature.com
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …
Unique features of long non-coding RNA biogenesis and function
Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous
biological processes across every branch of life. Although initially discovered as mRNA-like …
biological processes across every branch of life. Although initially discovered as mRNA-like …
Linking long noncoding RNA localization and function
LL Chen - Trends in biochemical sciences, 2016 - cell.com
Recent studies have revealed the regulatory potential of many long noncoding RNAs
(lncRNAs). Most lncRNAs, like mRNAs, are transcribed by RNA polymerase II and are …
(lncRNAs). Most lncRNAs, like mRNAs, are transcribed by RNA polymerase II and are …
Transcription termination and the control of the transcriptome: why, where and how to stop
O Porrua, D Libri - Nature reviews Molecular cell biology, 2015 - nature.com
Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …
thus delimitating transcription units; however, the functional importance of termination …
Native elongating transcript sequencing reveals human transcriptional activity at nucleotide resolution
Major features of transcription by human RNA polymerase II (Pol II) remain poorly defined
due to a lack of quantitative approaches for visualizing Pol II progress at nucleotide …
due to a lack of quantitative approaches for visualizing Pol II progress at nucleotide …
The role of FACT in managing chromatin: disruption, assembly, or repair?
Abstract FACT (FAcilitates Chromatin Transcription) has long been considered to be a
transcription elongation factor whose ability to destabilize nucleosomes promotes RNAPII …
transcription elongation factor whose ability to destabilize nucleosomes promotes RNAPII …
Emerging mechanisms of long noncoding RNA function during normal and malignant hematopoiesis
JR Alvarez-Dominguez… - Blood, The Journal of the …, 2017 - ashpublications.org
Long noncoding RNAs (lncRNAs) are increasingly recognized as vital components of gene
programs controlling cell differentiation and function. Central to their functions is an ability to …
programs controlling cell differentiation and function. Central to their functions is an ability to …
Native elongation transcript sequencing reveals temperature dependent dynamics of nascent RNAPII transcription in Arabidopsis
Temperature profoundly affects the kinetics of biochemical reactions, yet how large
molecular complexes such as the transcription machinery accommodate changing …
molecular complexes such as the transcription machinery accommodate changing …
Long noncoding RNAs as new architects in cancer epigenetics, prognostic biomarkers, and potential therapeutic targets
D Meseure, K Drak Alsibai, A Nicolas… - BioMed research …, 2015 - Wiley Online Library
Recent advances in genome‐wide analysis have revealed that 66% of the genome is
actively transcribed into noncoding RNAs (ncRNAs) while less than 2% of the sequences …
actively transcribed into noncoding RNAs (ncRNAs) while less than 2% of the sequences …