Pathogenicity and virulence of malaria: Sticky problems and tricky solutions

IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …

Cerebral malaria is associated with differential cytoadherence to brain endothelial cells

J Storm, JS Jespersen, KB Seydel… - EMBO Molecular …, 2019 - embopress.org
Sequestration of Plasmodium falciparum‐infected erythrocytes (IE) within the brain
microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow …

Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strains

JYA Doritchamou, R Morrison, JP Renn… - Communications …, 2019 - nature.com
Two vaccines based on Plasmodium falciparum protein VAR2CSA are currently in clinical
evaluation to prevent placental malaria (PM), but a deeper understanding of var2csa …

Interplay of Plasmodium falciparum and thrombin in brain endothelial barrier disruption

M Avril, M Benjamin, MM Dols, JD Smith - Scientific reports, 2019 - nature.com
Recent concepts suggest that both Plasmodium falciparum factors and coagulation
contribute to endothelial activation and dysfunction in pediatric cerebral malaria (CM) …

Cerebral malaria model applying human brain organoids

R Silva-Pedrosa, J Campos, AM Fernandes, M Silva… - Cells, 2023 - mdpi.com
Neural injuries in cerebral malaria patients are a significant cause of morbidity and mortality.
Nevertheless, a comprehensive research approach to study this issue is lacking, so herein …

Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria

DH Opi, CM Ndila, S Uyoga, AW Macharia… - PLoS …, 2023 - journals.plos.org
Blood group O is associated with protection against severe malaria and reduced size and
stability of P. falciparum-host red blood cell (RBC) rosettes compared to non-O blood …

Молекулы клеточной адгезии ICAM-1 и VCAM-1 при инфекционной патологии

ОВ Москалец - Тихоокеанский медицинский журнал, 2018 - cyberleninka.ru
Активация эндотелия важное звено иммунного ответа на инфекцию. От состояния
эндотелия зависят процессы миграции лейкоцитов в ткани из кровеносного русла. При …

Plasmodium falciparum in Aotus nancymaae: A New Model for Placental Malaria

A Sharma, B Jenkins, A Akue… - The Journal of …, 2022 - academic.oup.com
Plasmodium falciparum-infected erythrocytes that display the variant surface antigen
VAR2CSA bind chondroitin sulfate A (CSA) to sequester in placental intervillous spaces …

Glycophorin B-PfEMP1 interaction mediates robust rosetting in Plasmodium falciparum

B Deb, A Das, R Vilvadrinath, A Jangra… - International Journal of …, 2024 - Elsevier
P. falciparum erythrocyte membrane p rotein 1 (PfEMP1) is the major parasite protein
responsible for rosetting by binding to host receptors such as heparan sulfate, CR1 on RBC …

A novel locus in CSMD1 gene is associated with increased susceptibility to severe malaria in Malian children

D Damena, A Barry, R Morrison, S Gaoussou… - Frontiers in …, 2024 - frontiersin.org
Background Plasmodium falciparum malaria is still a leading cause of child mortality in sub-
Saharan Africa. The clinical manifestations of malaria range from asymptomatic infection to …