[PDF][PDF] The mechanism of biotin-dependent enzymes
TTR BIOTIN - Annu. Rev. Biochem, 1989 - scholar.archive.org
The enzymes that are involved in the metabolism of one-carbon units at the oxidation level
of carbon dioxide have a problem. Considerations of chemical reactivity would favor the …
of carbon dioxide have a problem. Considerations of chemical reactivity would favor the …
Hepatic glucose metabolism in humans—its role in health and disease
M Roden, E Bernroider - Best practice & research Clinical endocrinology & …, 2003 - Elsevier
The liver is mainly responsible for maintaining normal concentrations of blood glucose by its
ability to store glucose as glycogen and to produce glucose from glycogen breakdown or …
ability to store glucose as glycogen and to produce glucose from glycogen breakdown or …
TNF-α and IL-1α inhibit both pyruvate dehydrogenase activity and mitochondrial function in cardiomyocytes: evidence for primary impairment of mitochondrial function
R Zell, P Geck, K Werdan, P Boekstegers - Molecular and cellular …, 1997 - Springer
Cytokines such as tumor necrosis factor α (TNFα) and Interleukin-1α (IL1α) are known to
influence energy metabolism and mitochondrial function in tumor and vascular smooth …
influence energy metabolism and mitochondrial function in tumor and vascular smooth …
The structure and the mechanism of action of pyruvate carboxylase
PV Attwood - The international journal of biochemistry & cell biology, 1995 - Elsevier
Pyruvate carboxylase plays an important role in intermediary metabolism, catalysing the
formation of oxaloacetate from pyruvate and HCO3−, with concomitant ATP cleavage. It thus …
formation of oxaloacetate from pyruvate and HCO3−, with concomitant ATP cleavage. It thus …
AMPK inhibits liver gluconeogenesis: fact or fiction?
Is there a role for AMPK in the control of hepatic gluconeogenesis and could targeting AMPK
in liver be a viable strategy for treating type 2 diabetes? These are frequently asked …
in liver be a viable strategy for treating type 2 diabetes? These are frequently asked …
Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA
In this review we examine the effects of the allosteric activator, acetyl CoA on both the
structure and catalytic activities of pyruvate carboxylase. We describe how the binding of …
structure and catalytic activities of pyruvate carboxylase. We describe how the binding of …
New pharmacological approaches to therapy of NIDDM
R Bressler, D Johnson - Diabetes care, 1992 - Am Diabetes Assoc
Currently available pharmacological agents have not been completely successful in
restoring euglycemia in the non-insulin-dependent diabetes mellitus (NIDDM) patient …
restoring euglycemia in the non-insulin-dependent diabetes mellitus (NIDDM) patient …
[HTML][HTML] Elevated brain glutamate levels in bipolar disorder and pyruvate carboxylase-mediated anaplerosis
J Shen, JS Tomar - Frontiers in Psychiatry, 2021 - frontiersin.org
In vivo 1H magnetic resonance spectroscopy studies have found elevated brain glutamate
or glutamate+ glutamine levels in bipolar disorder with surprisingly high reproducibility. We …
or glutamate+ glutamine levels in bipolar disorder with surprisingly high reproducibility. We …
Plants contain multiple biotin enzymes: discovery of 3-methylcrotonyl-CoA carboxylase, propionyl-CoA carboxylase and pyruvate carboxylase in the plant kingdom
ES Wurtele, BJ Nikolau - Archives of Biochemistry and Biophysics, 1990 - Elsevier
Acetyl-CoA carboxylase is the sole biotin enzyme previously reported in plants. Western
analysis with 125 I-streptavidin of proteins extracted from carrot somatic embryos visualized …
analysis with 125 I-streptavidin of proteins extracted from carrot somatic embryos visualized …
In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase
JJ Bahl, M Matsuda, RA DeFronzo, R Bressler - Biochemical pharmacology, 1997 - Elsevier
The mechanism of inhibition of gluconeogenesis by phenylalkanoic acids was studied in
vitro and in vivo. In vitro production of 14CO2 from labeled glucose or palmitate was not …
vitro and in vivo. In vitro production of 14CO2 from labeled glucose or palmitate was not …