The enzymes that are involved in the metabolism of one-carbon units at the oxidation level
of carbon dioxide have a problem. Considerations of chemical reactivity would favor the …

The liver is mainly responsible for maintaining normal concentrations of blood glucose by its
ability to store glucose as glycogen and to produce glucose from glycogen breakdown or …

Cytokines such as tumor necrosis factor α (TNFα) and Interleukin-1α (IL1α) are known to
influence energy metabolism and mitochondrial function in tumor and vascular smooth …

Pyruvate carboxylase plays an important role in intermediary metabolism, catalysing the
formation of oxaloacetate from pyruvate and HCO3−, with concomitant ATP cleavage. It thus …

Is there a role for AMPK in the control of hepatic gluconeogenesis and could targeting AMPK
in liver be a viable strategy for treating type 2 diabetes? These are frequently asked …

In this review we examine the effects of the allosteric activator, acetyl CoA on both the
structure and catalytic activities of pyruvate carboxylase. We describe how the binding of …

Currently available pharmacological agents have not been completely successful in
restoring euglycemia in the non-insulin-dependent diabetes mellitus (NIDDM) patient …

In vivo 1H magnetic resonance spectroscopy studies have found elevated brain glutamate
or glutamate+ glutamine levels in bipolar disorder with surprisingly high reproducibility. We …

Acetyl-CoA carboxylase is the sole biotin enzyme previously reported in plants. Western
analysis with 125 I-streptavidin of proteins extracted from carrot somatic embryos visualized …

The mechanism of inhibition of gluconeogenesis by phenylalkanoic acids was studied in
vitro and in vivo. In vitro production of 14CO2 from labeled glucose or palmitate was not …