Peripheral neuropathy (PN) is a common neurological problem defined as a dysfunction of
sensory, motor, and autonomic nerves. The presence of peripheral neuropathy has recently …

Voltage-gated sodium channels (NaV¬) are the main contributors to action potential
generation and essential players in establishing neuronal excitability. NaV channels have …

Pioglitazone, an agonist at peroxisome proliferator-activated receptor gamma, is FDA-
approved for the treatment of insulin resistance in type 2 diabetes. Numerous studies in …

Mirogabalin (MGB, Tarlige®), an inhibitor of the α2δ-1 subunit of voltage-gated Ca2+ (CaV)
channels, is used as a way to alleviate peripheral neuropathic pain and diabetic neuropathy …

OBJECTIVE: Arabic gum Acacia (AG) is rich in fiber which improves lipid metabolism
besides its antioxidant effect. Folium mori (FM) is a widely used herb due to its …

Recent studies suggest a pathogenetic association between metabolic disturbances,
including type 2 diabetes (T2DM), and cognitive decline and indicate that T2DM may …

Although millions of people are diagnosed with cancer each year, survival has never been
greater thanks to early diagnosis and treatments. Powerful chemotherapeutic agents are …

Background Diabetic neuropathy (DN) is a serious microvascular complication and a major
cause of morbidity and mortality in diabetes mellitus. It is characterized by …

Background Ranolazine (Rn), an antianginal agent, acts in the central nervous system and
has been used as a potential treatment agent for pain and epileptic disorders. Alzheimer's …

DHA has been shown to be neuroprotective and important to neurogenesis, but its role in
HG-induced brain injury and the underlying mechanisms remain unknown. To elucidate the …