Oxidative stress (OS) has the ability to damage different molecules and cellular structures,
altering the correct function of organs and systems. OS accumulates in the body by …

Peroxisome proliferator-activated receptor α is a potent regulator of systemic and cellular
metabolism and energy homeostasis, but it also suppresses various inflammatory reactions …

Oxidative stress occurs due to the imbalance between the production of reactive oxygen
species (ROS) and the availability of antioxidants or radical scavengers. The excess ROS …

PPARα is a nuclear receptor that regulates liver and skeletal muscle lipid metabolism as
well as glucose homeostasis. Acting as a molecular sensor of endogenous fatty acids (FAs) …

Cells are richly equipped with nuclear receptors, which act as ligand-regulated transcription
factors. Peroxisome proliferator activated receptors (PPARs), members of the nuclear …

The involvement of both oxidative stress and hyperlipaemia in atherosclerosis development
is well established. Oxidative burst is an innate immune response to infection, the latter …

The worldwide prevalence of obesity and related metabolic disorders is rising rapidly,
increasing the burden on our healthcare system. Obesity is often accompanied by excess fat …

Peroxisome proliferator–activated receptors (PPARs) are ligand-activated transcription
factors involved in the transcriptional regulation of key metabolic pathways such as lipid …

Peroxisome proliferator-activated receptors (PPARs) and (liver X receptors) LXRs are ligand-
activated transcription factors that control lipid and glucose metabolism, as well as the …

Reactive oxygen species (ROS) contribute to several aspects of vascular diseases including
ischemia–reperfusion injury, scavenging of nitric oxide, or stimulation of inflammation and …