The hypothesis that pain can predispose to frailty development has been recently
investigated in several clinical studies suggesting that frailty and pain may share some …

This review focuses on our current understanding of vertebrate sex steroid receptors, with an
emphasis on their evolutionary relationships. These relationships are discussed based on …

Background Several brain disturbances have been described in association to type 1
diabetes in humans. In animal models, hippocampal pathological changes were reported …

Changes in hippocampal CA1 dendritic spine density and synaptic number across the
estrous cycle in female rats correlate with increased hippocampal-dependent cognitive …

Early expression of estrogen receptors (esr) and their role in regulating early expression of
cyp19a1b encoding brain aromatase were examined in the brain of zebrafish. Using in toto …

Neuropathy and encephalopathy represent important complications of diabetes. Recent
observations obtained in experimental models have suggested that, in male rats …

Background Hearing problems is one of the top ten public health disorders in the general
population and there is a well-established relationship between stress and hearing …

Millions of individuals suffer from age-related cognitive decline, defined by impaired memory
precision. Increased understanding of hippocampal circuit mechanisms underlying memory …

In humans the circulating concentrations of dehydroepiandrosterone (DHEA) and DHEA
sulfate (DHEAS) decrease markedly during aging, and have been implicated in age …

Over the last decades estrogen has been recognized to be involved in normal brain function
due to its neurothrophic and neuroprotective effects. Estrogen is intimately associated with …