Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

FWJ Chioh, SW Fong, BE Young, KX Wu, A Siau… - Elife, 2021 - elifesciences.org
Numerous reports of vascular events after an initial recovery from COVID-19 form our
impetus to investigate the impact of COVID-19 on vascular health of recovered patients. We …

Phenomic imaging

L Lan, K Feng, Y Wu, W Zhang, L Wei, H Che, L Xue… - Phenomics, 2023 - Springer
Human phenomics is defined as the comprehensive collection of observable phenotypes
and characteristics influenced by a complex interplay among factors at multiple scales …

Metabolomics and cardiovascular imaging: a combined approach for cardiovascular ageing

AS Koh, JP Kovalik - ESC Heart Failure, 2021 - Wiley Online Library
The purpose of this review is to explore how metabolomics can help uncover new
biomarkers and mechanisms for cardiovascular ageing. Cardiovascular ageing refers to …

[HTML][HTML] Validation of a rapid semi-automated method to assess left atrial longitudinal phasic strains on cine cardiovascular magnetic resonance imaging

S Leng, RS Tan, X Zhao, JC Allen, AS Koh… - Journal of Cardiovascular …, 2018 - Elsevier
Background Abnormal left atrial (LA) function is a marker of cardiac dysfunction and adverse
cardiovascular outcome, but is difficult to assess, and hence not, routinely quantified. We …

Normal values of myocardial deformation assessed by cardiovascular magnetic resonance feature tracking in a healthy Chinese population: a multicenter study

J Peng, X Zhao, L Zhao, Z Fan, Z Wang, H Chen… - Frontiers in …, 2018 - frontiersin.org
Reference values on atrial and ventricular strain from cardiovascular magnetic resonance
(CMR) are essential in identifying patients with impaired atrial and ventricular function …

Associations between skeletal muscle and myocardium in aging: a syndrome of “cardio‐sarcopenia”?

BMH Keng, F Gao, LLY Teo, WS Lim… - Journal of the …, 2019 - Wiley Online Library
Objectives The link between skeletal muscle and heart disease remains intriguing. It is
unknown how skeletal muscle may be associated with aspects of myocardial structure and …

Impaired cardiovascular magnetic resonance–derived rapid semiautomated right atrial longitudinal strain is associated with decompensated hemodynamics in …

S Leng, Y Dong, Y Wu, X Zhao, W Ruan… - Circulation …, 2019 - Am Heart Assoc
Background The transition of right ventricle (RV) from a compensated to decompensated
state contributes to survival in pulmonary arterial hypertension (PAH). This study …

Heart-brain mapping: Cardiac atrial function is associated with distinct cerebral regions with high free water in older adults

F Ji, JLK Wei, S Leng, L Zhong… - Journal of Cerebral …, 2024 - journals.sagepub.com
Left atrial (LA) dysfunction has been linked to cognitive impairment and cerebrovascular
dysfunction. Higher brain free-water (FW) derived from diffusion-MRI was associated with …

Amino acid differences between diabetic older adults and non-diabetic older adults and their associations with cardiovascular function

JP Kovalik, X Zhao, F Gao, S Leng, V Chow… - Journal of Molecular and …, 2021 - Elsevier
Background Ageing and insulin resistant states such as diabetes mellitus frequently coexist
and increase the risk of cardiovascular disease development among older adults. Here we …

Adverse cardiovascular and metabolic perturbations among older women:'fat-craving'hearts

JS Ho, JJ Wong, F Gao, HN Wee, LLY Teo… - Clinical Research in …, 2023 - Springer
Background Despite known sex-based differences in cardiovascular aging, differences in
aging biology are poorly understood. We hypothesize that circulating metabolites studied …