Morphogens are long-range signaling molecules that pattern developing tissues in a
concentration-dependent manner. The graded activity of morphogens within tissues …

The graded distribution of morphogens underlies many of the tissue patterns that form
during development. How morphogens disperse from a localized source and how gradients …

Spatiotemporal patterns of gene expression are fundamental to every developmental
program. The resulting macroscopic domains have been mainly characterized by their levels …

Early embryonic patterning events are strikingly precise, a fact that appears incompatible
with the stochastic gene expression observed across phyla. Using single-molecule mRNA …

Morphogen gradients direct the spatial patterning of developing embryos; however, the
mechanisms by which these gradients are interpreted remain elusive. Here we used lattice …

Gap genes are involved in segment determination during the early development of the fruit
fly Drosophila melanogaster as well as in other insects. This review attempts to synthesize …

The early Drosophila embryo is an ideal model to understand the transcriptional regulation
of well-defined patterns of gene expression in a developing organism [1]. In this system …

The Bicoid morphogen gradient directs the patterning of cell fates along the anterior-
posterior axis of the syncytial Drosophila embryo and serves as a paradigm of morphogen …

Morphogen gradients specify cell fates during development, with a classic example being
the bone morphogenetic protein (BMP) gradient's conserved role in embryonic dorsal …

We combine immunofluorescence and single-molecule fluorescence in situ hybridization
(smFISH), followed by automated image analysis, to quantify the concentration of nuclear …