Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert
their pro-angiogenic activity by interacting with various endothelial cell surface receptors …

Beyond an eminent role in hemostasis and thrombosis, platelets are characterized by expert
functions in assisting and modulating inflammatory reactions and immune responses. This is …

Angiogenesis, the formation of new blood vessels, is required for many pathologic
processes, including invasive tumor growth as well as physiologic organ/tissue …

The chemokines platelet factor 4 (PF4) and RANTES (regulated on activation normal T cell
expressed and secreted) are secreted by activated platelets and influence multiple cell types …

Angiogenesis, the process of formation of new blood vessel from pre-existing ones, is
involved in various intertwined pathological processes including virus infection …

Abstract BRAK/CXCL14 is a CXC chemokine constitutively expressed at the mRNA level in
certain normal tissues but absent from many established tumor cell lines and human …

Contents Angiogenesis is a process of vascular growth that is mainly limited to the
reproductive system in healthy adult animals. The development of new blood vessels in the …

Inhibition of angiogenesis is an important strategy to block tumor growth and invasion. We
discuss herein results from our ongoing investigations on platelet factor-4 (PF-4) and the …

ABSTRACT Platelet factor 4 (PF4) is an antiangiogenic ELR-negative chemokine. PF4
inhibits endothelial cell proliferation and migration and angiogenesis in vitro and in vivo …

Heparan sulfate (HS), a long linear polysaccharide of alternating disaccharide residues,
interacts with a wide variety of proteins, including many angiogenic factors. The involvement …