Engineering the next generation of cell-based therapeutics
Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …
intractable diseases through uniquely powerful modes of action. Despite notable recent …
Engineering living therapeutics with synthetic biology
A Cubillos-Ruiz, T Guo, A Sokolovska… - Nature Reviews Drug …, 2021 - nature.com
The steadfast advance of the synthetic biology field has enabled scientists to use genetically
engineered cells, instead of small molecules or biologics, as the basis for the development …
engineered cells, instead of small molecules or biologics, as the basis for the development …
Bioactive materials promote wound healing through modulation of cell behaviors
R Li, K Liu, X Huang, D Li, J Ding, B Liu… - Advanced …, 2022 - Wiley Online Library
Skin wound repair is a multistage process involving multiple cellular and molecular
interactions, which modulate the cell behaviors and dynamic remodeling of extracellular …
interactions, which modulate the cell behaviors and dynamic remodeling of extracellular …
Metal–organic frameworks and their composites for chronic wound healing: from bench to bedside
Y Xiong, Q Feng, L Lu, X Qiu, S Knoedler… - Advanced …, 2024 - Wiley Online Library
Chronic wounds are characterized by delayed and dysregulated healing processes. As
such, they have emerged as an increasingly significant threat. The associated morbidity and …
such, they have emerged as an increasingly significant threat. The associated morbidity and …
Immunomodulatory biomaterials for tissue repair
R Whitaker, B Hernaez-Estrada… - Chemical …, 2021 - ACS Publications
All implanted biomaterials are targets of the host's immune system. While the host
inflammatory response was once considered a detrimental force to be blunted or avoided, in …
inflammatory response was once considered a detrimental force to be blunted or avoided, in …
Foreign body reaction to implanted biomaterials and its impact in nerve neuroprosthetics
A Carnicer-Lombarte, ST Chen… - … in Bioengineering and …, 2021 - frontiersin.org
The implantation of any foreign material into the body leads to the development of an
inflammatory and fibrotic process—the foreign body reaction (FBR). Upon implantation into a …
inflammatory and fibrotic process—the foreign body reaction (FBR). Upon implantation into a …
Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies
Macrophages are a highly heterogeneous and plastic population of cells that are crucial for
tissue repair and regeneration. This has made macrophages a particularly attractive target …
tissue repair and regeneration. This has made macrophages a particularly attractive target …
The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans
Silicone is widely used in chronic implants and is generally perceived to be safe. However,
textured breast implants have been associated with immune-related complications …
textured breast implants have been associated with immune-related complications …
Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing
DR Griffin, MM Archang, CH Kuan, WM Weaver… - Nature materials, 2021 - nature.com
Microporous annealed particle (MAP) scaffolds are flowable, in situ crosslinked,
microporous scaffolds composed of microgel building blocks and were previously shown to …
microporous scaffolds composed of microgel building blocks and were previously shown to …
Dealing with the foreign‐body response to implanted biomaterials: strategies and applications of new materials
D Zhang, Q Chen, C Shi, M Chen, K Ma… - Advanced Functional …, 2021 - Wiley Online Library
Foreign‐body response caused by implanted biomaterials seriously impedes the function of
implants and is a major obstacle to the development of implantable biomaterials and …
implants and is a major obstacle to the development of implantable biomaterials and …