Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …

The steadfast advance of the synthetic biology field has enabled scientists to use genetically
engineered cells, instead of small molecules or biologics, as the basis for the development …

Skin wound repair is a multistage process involving multiple cellular and molecular
interactions, which modulate the cell behaviors and dynamic remodeling of extracellular …

Chronic wounds are characterized by delayed and dysregulated healing processes. As
such, they have emerged as an increasingly significant threat. The associated morbidity and …

All implanted biomaterials are targets of the host's immune system. While the host
inflammatory response was once considered a detrimental force to be blunted or avoided, in …

The implantation of any foreign material into the body leads to the development of an
inflammatory and fibrotic process—the foreign body reaction (FBR). Upon implantation into a …

Macrophages are a highly heterogeneous and plastic population of cells that are crucial for
tissue repair and regeneration. This has made macrophages a particularly attractive target …

Silicone is widely used in chronic implants and is generally perceived to be safe. However,
textured breast implants have been associated with immune-related complications …

Microporous annealed particle (MAP) scaffolds are flowable, in situ crosslinked,
microporous scaffolds composed of microgel building blocks and were previously shown to …

Foreign‐body response caused by implanted biomaterials seriously impedes the function of
implants and is a major obstacle to the development of implantable biomaterials and …