Hyponatremia is a serious, but often overlooked, electrolyte imbalance that has been
independently associated with a wide range of deleterious changes involving many different …

Drug-induced hyponatremia caused by renal water retention is mainly due to syndrome of
inappropriate antidiuresis (SIAD). SIAD can be grouped into syndrome of inappropriate …

The water channel aquaporin-2 (AQP2), expressed in the kidney collecting ducts, plays a
pivotal role in maintaining body water balance. The channel is regulated by the peptide …

Hypernatremia is defined as a serum sodium level above 145 mmol/L. It is a frequently
encountered electrolyte disturbance in the hospital setting, with an unappreciated high …

Abstract Background Aquaporins (AQPs) are a family of proteins that can act as water
channels. Regulation of AQPs is critical to osmoregulation and the maintenance of body …

Diabetes insipidus (DI) is an endocrine condition involving the posterior pituitary peptide
hormone, antidiuretic hormone (ADH). ADH exerts its effects on the distal convoluted tubule …

Diabetes insipidus (DI) is a hereditary or acquired condition which disrupts normal life of
persons with the condition; disruption is due to increased thirst and passing of large volumes …

Background: The syndrome of inappropriate antidiuresis (SIAD) is the most frequent cause
of hyponatremia. Its diagnosis requires decreased serum osmolality, inappropriately diluted …

Results Patients (age 45±8 years, 54% women, measured GFR of 55±11 ml/min per 1.73 m
2) had a baseline urine volume on tolvaptan of 6.9±1.4 L/24 h. Urine volume decreased to …

The anti-diuretic hormone arginine vasopressin (AVP) is released from the pituitary upon
hypovolemia or hypernatremia, and regulates water reabsorption in the renal collecting duct …