Besides the physiological regulation of water, sodium, and potassium homeostasis,
aldosterone modulates several physiological and pathological processes in the …

The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …

Central serous chorioretinopathy (CSCR) is a vision-threatening eye disease with no
validated treatment and unknown pathogeny. In CSCR, dilation and leakage of choroid …

Patients with heart failure experience a number of changes in the electrical function of the
heart that predispose to potentially lethal cardiac arrhythmias. Action potential prolongation …

Despite recent advances in preventing sudden cardiac death (SCD) due to cardiac
arrhythmia, its incidence in the population at large has remained unacceptably high. Better …

Background and aim Considering the amount of novel knowledge generated in the last five
years, a team of experienced hypertensionlogists was assembled to furnish updated clinical …

Cardiovascular disease is the leading cause of death in the diabetic population. However,
molecular mechanisms underlying diabetic cardiomyopathy remain unclear. We analyzed …

Background—Life-threatening cardiac arrhythmia is a major source of mortality worldwide.
Besides rare inherited monogenic diseases such as long-QT or Brugada syndromes, which …

cAMP is a powerful second messenger whose known general effector is protein kinase A
(PKA). The identification of a cAMP binding protein, Epac, raises the question of its role in …

In our opinion, one of the most important—and vexing—questions in clinical cardiology
today can be phrased quite simply:“Why did he die on Tuesday and not on Monday?” 1 …