Novel prediction equations for absolute risk assessment of total cardiovascular disease incorporating cardiovascular-kidney-metabolic health: a scientific statement …

SS Khan, J Coresh, MJ Pencina, CE Ndumele… - Circulation, 2023 - Am Heart Assoc
Cardiovascular-kidney-metabolic (CKM) syndrome is a novel construct recently defined by
the American Heart Association in response to the high prevalence of metabolic and kidney …

Lipoprotein (a) and cardiovascular and valvular diseases: a genetic epidemiological perspective

BJ Arsenault, PR Kamstrup - Atherosclerosis, 2022 - Elsevier
Rates of atherosclerotic cardiovascular diseases (CVD) in the Western world have
spectacularly decreased over the past 50 years. However, a substantial proportion of high …

Muvalaplin, an oral small molecule inhibitor of lipoprotein (a) formation: a randomized clinical trial

SJ Nicholls, SE Nissen, C Fleming, S Urva, J Suico… - Jama, 2023 - jamanetwork.com
Importance Lipoprotein (a)(Lp [a]) is associated with atherosclerotic disease and aortic
stenosis. Lp (a) forms by bonding between apolipoprotein (a)(apo [a]) and apo B 100 …

Targeting the liver with nucleic acid therapeutics for the treatment of systemic diseases of liver origin

A Gogate, J Belcourt, M Shah, AZ Wang… - Pharmacological …, 2024 - ASPET
Systemic diseases of liver origin (SDLO) are complex diseases in multiple organ systems,
such as cardiovascular, musculoskeletal, endocrine, renal, respiratory, and sensory organ …

Concordance of a high lipoprotein (a) concentration among relatives

LF Reeskamp, TR Tromp, AP Patel, S Ibrahim… - JAMA …, 2023 - jamanetwork.com
Importance Lipoprotein (a)(Lp [a]) concentrations are a highly heritable and potential causal
risk factor for atherosclerotic cardiovascular disease (ASCVD). Recent consensus …

Sex-specific differences in lipoprotein production and clearance

DM Conlon, FK Welty, G Reyes-Soffer… - … , and vascular biology, 2023 - Am Heart Assoc
Therapeutic approaches to reduce atherogenic lipid and lipoprotein levels remain the most
effective and assessable strategies to prevent and treat cardiovascular disease. The …

Triglyceride-rich lipoproteins, remnant-cholesterol, and atherosclerotic cardiovascular disease

OP Ganda - Current Opinion in Lipidology, 2023 - journals.lww.com
Triglyceride-rich lipoproteins, remnant-cholesterol, and ath... : Current Opinion in Lipidology
Triglyceride-rich lipoproteins, remnant-cholesterol, and atherosclerotic cardiovascular disease …

Relating lipoprotein (a) concentrations to cardiovascular event risk after acute coronary syndrome: a comparison of 3 tests

M Szarek, E Reijnders, JW Jukema, DL Bhatt… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Lipoprotein (a) is a risk factor for cardiovascular events and modifies the
benefit of PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors. Lipoprotein (a) …

Lipoprotein (a)—60 years later—what do we know?

A Pasławska, PJ Tomasik - Cells, 2023 - mdpi.com
Lipoprotein (a)(Lp (a)) molecule includes two protein components: apolipoprotein (a) and
apoB100. The molecule is the main transporter of oxidized phospholipids (OxPL) in plasma …

Associations of homeostatic model assessment for insulin resistance trajectories with cardiovascular disease incidence and mortality

JH Lee, S Jeon, B Joung, HS Lee… - … thrombosis, and vascular …, 2023 - Am Heart Assoc
Background: Whether trends in insulin resistance changes are related to the risk of
cardiovascular disease (CVD) incidence and mortality remains unclear. We aimed to …