Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

Candida parapsilosis: from genes to the bedside

R Tóth, J Nosek, HM Mora-Montes… - Clinical microbiology …, 2019 - Am Soc Microbiol
Patients with suppressed immunity are at the highest risk for hospital-acquired infections.
Among these, invasive candidiasis is the most prevalent systemic fungal nosocomial …

Non-coding RNAs in cancer: Platforms and strategies for investigating the genomic “dark matter”

K Grillone, C Riillo, F Scionti, R Rocca… - Journal of Experimental …, 2020 - Springer
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of
malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are …

Long non-coding RNAs: mechanisms, experimental, and computational approaches in identification, characterization, and their biomarker potential in cancer

A Chowdhary, V Satagopam, R Schneider - Frontiers in Genetics, 2021 - frontiersin.org
Long non-coding RNAs are diverse class of non-coding RNA molecules> 200 base pairs of
length having various functions like gene regulation, dosage compensation, epigenetic …

Secondary structure prediction of long noncoding RNA: review and experimental comparison of existing approaches

LA Bugnon, AA Edera, S Prochetto… - Briefings in …, 2022 - academic.oup.com
Motivation In contrast to messenger RNAs, the function of the wide range of existing long
noncoding RNAs (lncRNAs) largely depends on their structure, which determines …

A hybrid approach to assess the structural impact of long noncoding RNA mutations uncovers key NEAT1 interactions in colorectal cancer

E Aydın, E Saus, U Chorostecki, T Gabaldón - IUBMB life, 2023 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are emerging players in cancer and they entail potential
as prognostic biomarkers or therapeutic targets. Earlier studies have identified somatic …

Probing RNA structural landscapes across Candida yeast genomes

U Chorostecki, E Saus, T Gabaldón - Frontiers in Microbiology, 2024 - frontiersin.org
Understanding the intricate roles of RNA molecules in virulence and host-pathogen
interactions can provide valuable insights into combatting infections and improving human …

Chemical and enzymatic probing of viral RNAs: From infancy to maturity and beyond

O Gilmer, E Quignon, AC Jousset, JC Paillart… - Viruses, 2021 - mdpi.com
RNA molecules are key players in a variety of biological events, and this is particularly true
for viral RNAs. To better understand the replication of those pathogens and try to block them …

RNA structure elements conserved between mouse and 59 other vertebrates

BC Thiel, R Ochsenreiter, VP Gadekar, A Tanzer… - Genes, 2018 - mdpi.com
In this work, we present a computational screen conducted for functional RNA structures,
resulting in over 100,000 conserved RNA structure elements found in alignments of mouse …

Transcriptome sequencing approaches to elucidate host–microbe interactions in opportunistic human fungal pathogens

H Hovhannisyan, T Gabaldón - Fungal Physiology and …, 2019 - Springer
Infections caused by opportunistic human fungal pathogens are a source of increasing
medical concern, due to their growing incidence, the emergence of novel pathogenic …