Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

Traumatic spinal cord injury (SCI) can cause severe neurological impairments. Clinically
available treatments are quite limited, with unsatisfactory remediation effects. Residing …

The etiology of many neurological diseases affecting the central nervous system (CNS) is
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …

Spinal cord injury (SCI) is a central nervous system (CNS) devastate event that is commonly
caused by traumatic or non-traumatic events. The reinnervation of spinal cord axons is …

Nucleic acid (NA) therapeutics are a rapidly growing class of biomedicines with the ability to
manipulate gene expression in potent and specific manner, and with the enormous potential …

Significance: Traumatic spinal cord injury (SCI) causes significant disruption to neuronal,
glial, vascular, and extracellular elements. The spinal cord extracellular matrix (ECM) …

Spinal cord injury (SCI) is a devastating central nervous system disease caused by
accidental events, resulting in loss of sensory and motor function. Considering the multiple …

Abstract Oxidation resistance 1 (OXR1) is regarded as a critical regulator of cellular
homeostasis in response to oxidative stress. However, the role of OXR1 in the neuronal …

Exosomes are nanoscale-sized membrane vesicles released by cells into their extracellular
milieu. Within these nanovesicles reside a multitude of bioactive molecules, which …

Regeneration is bungled following CNS injuries, including spinal cord injury (SCI). Inherent
decay of permissive conditions restricts the regrowth of the mature CNS after an injury …