Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …

The zebrafish has become a prominent vertebrate model for disease and has already
contributed to several examples of successful phenotype-based drug discovery. For the …

Genome-wide association studies have identified risk loci linked to inflammatory bowel
disease (IBD)—a complex chronic inflammatory disorder of the gastrointestinal tract. The …

Ketogenic diets recapitulate certain metabolic aspects of dietary restriction such as reliance
on fatty acid metabolism and production of ketone bodies. We investigated whether an …

Metabolic associated fatty liver disease (MAFLD) encompasses a broad spectrum of hepatic
disorders, including steatosis, nonalcoholic steatohepatitis (NASH) and fibrosis. We …

The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Plastic nanoparticles originating from weathering plastic waste are emerging contaminants
in aquatic environments, with unknown modes of action in aquatic organisms. Recent …

As the incidence of hepatobiliary diseases increases, we must improve our understanding of
the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver …

Pancreatic β-cells form highly connected networks within isolated islets. Whether this
behaviour pertains to the situation in vivo, after innervation and during continuous perfusion …

The zebrafish research community is celebrating! The zebrafish genome has recently been
sequenced, the Zebrafish Mutation Project (launched by the Wellcome Trust Sanger …