An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

200 billion red blood cells (RBCs) are produced every day, requiring more than 2× 10 15
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …

Iron is an essential element that is indispensable for life. The delicate physiological body
iron balance is maintained by both systemic and cellular regulatory mechanisms. The iron …

Modified tetrapyrroles are large macrocyclic compounds, consisting of diverse conjugation
and metal chelation systems and imparting an array of colors to the biological structures that …

Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …

Iron is a transition metal that due to its inherent ability to exchange electrons with a variety of
molecules is essential to support life. In mammals, iron exists mostly in the form of heme …

The advent of heme during evolution allowed organisms possessing this compound to
safely and efficiently carry out a variety of chemical reactions that otherwise were difficult or …

Bacterial pathogens require the iron-containing cofactor heme to cause disease. Heme is
essential to the function of hemoproteins, which are involved in energy generation by the …

Microscopy and mass spectrometry (MS) are complementary techniques: The former
provides spatiotemporal information in living cells, but only for a handful of recombinant …

Mitochondria fulfill central functions in bioenergetics, metabolism, and apoptosis. They
import more than 1,000 different proteins from the cytosol. It had been assumed that the …