Lineage plasticity in cancer: a shared pathway of therapeutic resistance
Lineage plasticity, the ability of cells to transition from one committed developmental
pathway to another, has been proposed as a source of intratumoural heterogeneity and of …
pathway to another, has been proposed as a source of intratumoural heterogeneity and of …
Genomic and phenotypic heterogeneity in prostate cancer
From a clinical, morphological and molecular perspective, prostate cancer is a
heterogeneous disease. Primary prostate cancers are often multifocal, having …
heterogeneous disease. Primary prostate cancers are often multifocal, having …
Androgen receptor activity in T cells limits checkpoint blockade efficacy
Immune checkpoint blockade has revolutionized the field of oncology, inducing durable anti-
tumour immunity in solid tumours. In patients with advanced prostate cancer …
tumour immunity in solid tumours. In patients with advanced prostate cancer …
Biologically informed deep neural network for prostate cancer discovery
The determination of molecular features that mediate clinically aggressive phenotypes in
prostate cancer remains a major biological and clinical challenge,. Recent advances in …
prostate cancer remains a major biological and clinical challenge,. Recent advances in …
FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer
M Han, F Li, Y Zhang, P Dai, J He, Y Li, Y Zhu, J Zheng… - Cancer Cell, 2022 - cell.com
Prostate cancer adeno-to-neuroendocrine lineage transition has emerged as a mechanism
of targeted therapeutic resistance. Identifying the direct molecular drivers and developing …
of targeted therapeutic resistance. Identifying the direct molecular drivers and developing …
Genomic correlates of clinical outcome in advanced prostate cancer
Heterogeneity in the genomic landscape of metastatic prostate cancer has become apparent
through several comprehensive profiling efforts, but little is known about the impact of this …
through several comprehensive profiling efforts, but little is known about the impact of this …
The DNA methylation landscape of advanced prostate cancer
Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …
methylation landscape of metastatic cancer has never been defined. Through whole …
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC)
EEW Cohen, RB Bell, CB Bifulco, B Burtness… - … for immunotherapy of …, 2019 - Springer
Head and neck cancers, including those of the lip and oral cavity, nasal cavity, paranasal
sinuses, oropharynx, larynx and nasopharynx represent nearly 700,000 new cases and …
sinuses, oropharynx, larynx and nasopharynx represent nearly 700,000 new cases and …
An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer
ML Burr, CE Sparbier, KL Chan, YC Chan… - Cancer cell, 2019 - cell.com
Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy
resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved …
resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved …
Clinical and biological features of neuroendocrine prostate cancer
Y Yamada, H Beltran - Current oncology reports, 2021 - Springer
Abstract Purpose of Review Neuroendocrine prostate cancer (NEPC) is an aggressive
histologic subtype of prostate cancer that most commonly arises in later stages of prostate …
histologic subtype of prostate cancer that most commonly arises in later stages of prostate …