The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated
manner with protein tyrosine kinases to control signalling pathways that underlie a broad …

Tyrosine phosphorylation is an important signalling mechanism in eukaryotic cells. In
cancer, oncogenic activation of tyrosine kinases is a common feature, and novel anticancer …

Choline dietary intake varies such that many people do not achieve adequate intakes. Diet
intake of choline can modulate methylation because, via betaine homocysteine …

MicroRNAs (miRs) are conserved small non‐coding RNAs that negatively regulate gene
expression. The miR profiles are markedly altered in cancers and some of them have a …

MicroRNAs (miR) are a class of small (∼ 21 nucleotide) noncoding RNAs that, in general,
negatively regulate gene expression. Some miRs harboring CGIs undergo methylation …

Azacytidine-and 5-aza-deoxycytidine (5-aza-CdR)-mediated reactivation of tumor
suppressor genes silenced by promoter methylation has provided an alternate approach in …

Despite an increase in survival for children with acute lymphoblastic leukemia (ALL), the
outcome after relapse is poor. To understand the genetic events that contribute to relapse …

The aberrant activation of oncogenic signaling pathways is a universal phenomenon in
cancer and drives tumorigenesis and malignant transformation. This abnormal activation of …

Purpose To analyze the occurrence of promoter hypermethylation in primary cutaneous T-
cell lymphoma (CTCL) on a genome-wide scale, focusing on epigenetic alterations with …

The methylation status of the CpG island located within the ribosomal RNA (rRNA) promoter
in human hepatocellular carcinomas and pair-matched liver tissues was analyzed by …