Despite numerous guidelines on the management of anaemia in surgical patients, there is
no pragmatic guidance for the diagnosis and management of anaemia and iron deficiency in …

Background The optimal haemoglobin threshold for use of red blood cell (RBC) transfusions
in anaemic patients remains an active field of research. Blood is a scarce resource, and in …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Importance Red blood cell transfusion is a common medical intervention with benefits and
harms. Objective To provide recommendations for use of red blood cell transfusion in adults …

Importance Blood transfusion is one of the most frequently used therapies worldwide and is
associated with benefits, risks, and costs. Objective To develop a set of evidence-based …

Objective To develop evidence-based clinical practice recommendations regarding
transfusion practices in non-bleeding, critically ill adults. Design A task force involving 13 …

Background Several new trials evaluating transfusion strategies in patients with
cardiovascular disease have recently been published, increasing the number of enrolled …

Importance Red blood cell (RBC) transfusion is common among patients admitted to the
intensive care unit (ICU). Despite multiple randomized clinical trials of hemoglobin (Hb) …

Among critically ill adults, sepsis remains both common and lethal. In addition to antibiotics
and source control, fluid resuscitation is a fundamental sepsis therapy. The physiology of …

Sepsis is a clinical syndrome encompassing physiologic and biological abnormalities
caused by a dysregulated host response to infection. Sepsis progression into septic shock is …