Cellular plasticity and the neuroendocrine phenotype in prostate cancer
The success of next-generation androgen receptor (AR) pathway inhibitors, such as
abiraterone acetate and enzalutamide, in treating prostate cancer has been hampered by …
abiraterone acetate and enzalutamide, in treating prostate cancer has been hampered by …
[HTML][HTML] Animal models of Parkinson's disease: bridging the gap between disease hallmarks and research questions
A Dovonou, C Bolduc, V Soto Linan, C Gora… - Translational …, 2023 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …
[HTML][HTML] Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson's disease
BM Hiller, DJ Marmion, CA Thompson… - NPJ Regenerative …, 2022 - nature.com
In pursuit of treating Parkinson's disease with cell replacement therapy, differentiated
induced pluripotent stem cells (iPSC) are an ideal source of midbrain dopaminergic (mDA) …
induced pluripotent stem cells (iPSC) are an ideal source of midbrain dopaminergic (mDA) …
Aberrant epigenome in iPSC‐derived dopaminergic neurons from Parkinson's disease patients
R Fernández‐Santiago, I Carballo‐Carbajal… - EMBO molecular …, 2015 - embopress.org
The epigenomic landscape of Parkinson's disease (PD) remains unknown. We performed a
genomewide DNA methylation and a transcriptome studies in induced pluripotent stem cell …
genomewide DNA methylation and a transcriptome studies in induced pluripotent stem cell …
[HTML][HTML] Role of primary aging hallmarks in Alzheimer´ s disease
J Zhao, J Huai - Theranostics, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …
threatens the health of the elderly and causes significant economic and social burdens. The …
[HTML][HTML] Dicer and microRNAs protect adult dopamine neurons
MicroRNAs (miRs) are important post-transcriptional regulators of gene expression
implicated in neuronal development, differentiation, aging and neurodegenerative diseases …
implicated in neuronal development, differentiation, aging and neurodegenerative diseases …
FoxO proteins in the nervous system
K Maiese - Analytical cellular pathology, 2015 - Wiley Online Library
Acute as well as chronic disorders of the nervous system lead to significant morbidity and
mortality for millions of individuals globally. Given the ability to govern stem cell proliferation …
mortality for millions of individuals globally. Given the ability to govern stem cell proliferation …
Back and to the future: from neurotoxin‐induced to human Parkinson's disease models
Parkinson's disease (PD) is an age‐related neurodegenerative disorder characterized by
motor symptoms such as tremor, slowness of movement, rigidity, and postural instability, as …
motor symptoms such as tremor, slowness of movement, rigidity, and postural instability, as …
[HTML][HTML] Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson's disease
In addition to the well-known degeneration of midbrain dopaminergic neurons, enteric
neurons can also be affected in neurodegenerative disorders such as Parkinson's disease …
neurons can also be affected in neurodegenerative disorders such as Parkinson's disease …
Transcription networks rewire gene repertoire to coordinate cellular reprograming in prostate cancer
Transcription factors (TFs) represent the most commonly deregulated DNA-binding class of
proteins associated with multiple human cancers. They can act as transcriptional activators …
proteins associated with multiple human cancers. They can act as transcriptional activators …