[HTML][HTML] Microbiota in health and diseases

K Hou, ZX Wu, XY Chen, JQ Wang, D Zhang… - Signal transduction and …, 2022 - nature.com
The role of microbiota in health and diseases is being highlighted by numerous studies
since its discovery. Depending on the localized regions, microbiota can be classified into …

Monounsaturated fatty acids in obesity-related inflammation

G Ravaut, A Légiot, KF Bergeron… - International journal of …, 2020 - mdpi.com
Obesity is an important aspect of the metabolic syndrome and is often associated with
chronic inflammation. In this context, inflammation of organs participating in energy …

Metabolomics signatures in type 2 diabetes: a systematic review and integrative analysis

Y Sun, HY Gao, ZY Fan, Y He… - The Journal of Clinical …, 2020 - academic.oup.com
Objective Metabolic signatures have emerged as valuable signaling molecules in the
biochemical process of type 2 diabetes (T2D). To summarize and identify metabolic …

The biological functions and regulatory mechanisms of fatty acid binding protein 5 in various diseases

B Xu, L Chen, Y Zhan, KNS Marquez, L Zhuo… - Frontiers in cell and …, 2022 - frontiersin.org
In recent years, fatty acid binding protein 5 (FABP5), also known as fatty acid transporter,
has been widely researched with the help of modern genetic technology. Emerging …

Lipotoxicity and β-cell failure in type 2 diabetes: Oxidative stress linked to NADPH oxidase and ER stress

EA Vilas-Boas, DC Almeida, LP Roma, F Ortis… - Cells, 2021 - mdpi.com
A high caloric intake, rich in saturated fats, greatly contributes to the development of obesity,
which is the leading risk factor for type 2 diabetes (T2D). A persistent caloric surplus …

Adipose tissue secretion pattern influences β-cell wellness in the transition from obesity to type 2 diabetes

G Biondi, N Marrano, A Borrelli, M Rella… - International Journal of …, 2022 - mdpi.com
The dysregulation of the β-cell functional mass, which is a reduction in the number of β-cells
and their ability to secure adequate insulin secretion, represents a key mechanistic factor …

Selenium Nanodots (SENDs) as Antioxidants and Antioxidant‐Prodrugs to Rescue Islet β Cells in Type 2 Diabetes Mellitus by Restoring Mitophagy and Alleviating …

Q Huang, Z Liu, Y Yang, Y Yang, T Huang… - Advanced …, 2023 - Wiley Online Library
Preventing islet β‐cells death is crucial for treating type 2 diabetes mellitus (T2DM).
Currently, clinical drugs are being developed to improve the quality of T2DM care and self …

Molecular mechanism of palmitic acid and its derivatives in tumor progression

X Wang, C Zhang, N Bao - Frontiers in oncology, 2023 - frontiersin.org
Palmitic acid (PA) is a saturated fatty acid commonly found in coconut oil and palm oil. It
serves as an energy source for the body and plays a role in the structure and function of cell …

METTL3 mediates osteoblast apoptosis by regulating endoplasmic reticulum stress during LPS-induced inflammation

Y Kong, Y Zhang, Y Cai, D Li, B Yi, Q Xu - Cellular Signalling, 2022 - Elsevier
Osteoblast apoptosis is a prominent factor for disrupting skeletal homeostasis in multiple
inflammatory bone diseases. METTL3, a key methyltransferase that catalyzes the N6 …

Molecular mechanisms of apoptosis induction and its regulation by fatty acids in pancreatic β-cells

J Šrámek, V Němcová-Fürstová, J Kovář - International Journal of …, 2021 - mdpi.com
Pancreatic β-cell failure and death contribute significantly to the pathogenesis of type 2
diabetes. One of the main factors responsible for β-cell dysfunction and subsequent cell …