Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans
The nematode C. elegans (worm) is a small invertebrate animal widely used in studies
related to fundamental biological processes, disease modelling, and drug discovery. Due to …
related to fundamental biological processes, disease modelling, and drug discovery. Due to …
Multiscale brain research on a microfluidic chip
One major challenge in current brain research is generating an integrative understanding of
the brain's functions and disorders from its multiscale neuronal architectures and …
the brain's functions and disorders from its multiscale neuronal architectures and …
Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of Caenorhabditis elegans and its functional response to drugs
JE Hewitt, AK Pollard… - Disease models & …, 2018 - journals.biologists.com
Muscle strength is a key clinical parameter used to monitor the progression of human
muscular dystrophies, including Duchenne and Becker muscular dystrophies. Although …
muscular dystrophies, including Duchenne and Becker muscular dystrophies. Although …
NemaFlex: a microfluidics-based technology for standardized measurement of muscular strength of C. elegans
Muscle strength is a functional measure of quality of life in humans. Declines in muscle
strength are manifested in diseases as well as during inactivity, aging, and space travel …
strength are manifested in diseases as well as during inactivity, aging, and space travel …
Biophysical analysis of drug efficacy on C. elegans models for neurodegenerative and neuromuscular diseases
Caenorhabditis elegans has emerged as a powerful model organism for drug screening due
to its cellular simplicity, genetic amenability and homology to humans combined with its …
to its cellular simplicity, genetic amenability and homology to humans combined with its …
Microfluidic platform for integrated compartmentalization of single zoospores, germination and measurement of protrusive force generated by germ tubes
This paper describes the design, fabrication and characterisation of a novel monolithic lab-
on-a-chip (LOC) platform combining the trapping and germination of individual zoospores of …
on-a-chip (LOC) platform combining the trapping and germination of individual zoospores of …
Phenotyping of the thrashing forces exerted by partially immobilized C. elegans using elastomeric micropillar arrays
As a simple model organism, C. elegans plays an important role in gaining insight into the
relationship between bodily thrashing forces and biological effects, such as disease and …
relationship between bodily thrashing forces and biological effects, such as disease and …
Platforms for high-throughput screening and force measurements on fungi and oomycetes
Pathogenic fungi and oomycetes give rise to a significant number of animal and plant
diseases. While the spread of these pathogenic microorganisms is increasing globally …
diseases. While the spread of these pathogenic microorganisms is increasing globally …
An economical and highly adaptable optogenetics system for individual and population-level manipulation of Caenorhabditis elegans
M Koopman, L Janssen, EAA Nollen - BMC biology, 2021 - Springer
Background Optogenetics allows the experimental manipulation of excitable cells by a light
stimulus without the need for technically challenging and invasive procedures. The high …
stimulus without the need for technically challenging and invasive procedures. The high …
Neuroscience research using small animals on a chip: from nematodes to zebrafish larvae
Implementation of microfluidic technology to study small animal models such as
Caenorhabditis elegans worms (soil-dwelling nematodes), Drosophila melanogaster (fruit …
Caenorhabditis elegans worms (soil-dwelling nematodes), Drosophila melanogaster (fruit …