Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Abstract Purpose of Review With the intention to summarize the currently available evidence
on the pathophysiological relevance of inflammation in heart failure, this review addresses …

The therapeutic targeting of extracellular proteins is becoming hugely attractive in light of
evidence implicating the tumour microenvironment as pivotal in all aspects of tumour …

Overlapping pandemics of lifestyle-related diseases pose a substantial threat to
cardiovascular health. Apart from coronary artery disease, metabolic disturbances linked to …

The tumor microenvironment is essential for the formation and development of tumors.
Cytokines in the microenvironment may affect the growth, metastasis and prognosis of …

Simple Summary To improve efficacy of solid cancer treatment, efforts have shifted towards
targeting both the cancer cells and the surrounding tumour tissue they grow in. The lysyl …

Lysyl oxidase (LOX) family oxidases, LOX and LOXL1-4, oxidize lysine residues in
collagens and elastin, resulting in the covalent crosslinking and stabilization of these …

The lysyl oxidase (LOX) family of oxidases contains a group of extracellular copper-
dependent enzymes that catalyze the cross-linking of collagen and elastin by oxidation, thus …

Abstract Purpose of Review Cardiovascular diseases are the leading cause of death
worldwide, largely due to the limited regenerative capacity of the adult human heart. In …

Cu-dependent lysyl oxidase (LOX) plays a catalytic activity-related, primary role in the
assembly of the extracellular matrix (ECM), a dynamic structural and regulatory framework …