Obesity has reached epidemic proportions and its prevalence is climbing. Obesity is
characterized by hypertrophied adipocytes with a dysregulated adipokine secretion profile …

Highlights•Arginase plays a key role in the development of asthma and COPD.•Disrupted l-
arginine homeostasis may contribute to the emergence of co-morbidities.•Local use of …

Psoriasis is a chronic inflammatory disease whose etiology is multifactorial. The
contributions of cellular metabolism to psoriasis are unclear. Here, we report that interleukin …

Growing evidence highlights the role of arginase activity in the manifestation of Alzheimer's
disease (AD). Upregulation of arginase was shown to contribute to neurodegeneration …

Nonalcoholic fatty liver disease (NAFLD) associates with obesity and type 2 diabetes.
Hypoactive AMP-activated protein kinase (AMPK), hyperactive m ammalian t arget ofr …

Upregulated arginase activity, which competes with nitric oxide synthase (NOS), impairs
nitric oxide production and has been implicated in various metabolic disorders. This study …

Arginase may play a major role in the regulation of vascular function in various
cardiovascular disorders by impairing nitric oxide (NO) production. In the current study, we …

This study investigated the temporal activation of arginase in obese Zucker rats (ZR) and
determined if arginase inhibition prevents the development of hypertension and improves …

Visceral adipose tissue (VAT) inflammation and metabolic dysregulation are key
components of obesity-induced metabolic disease. Upregulated arginase, a ureahydrolase …

Background There is growing interest in the supplementation of arginine (Arg) and citrulline
(Cit) in obesity due to their potential anti-obesogenic and anti-inflammatory properties …