Detecting epistasis in human complex traits

WH Wei, G Hemani, CS Haley - Nature Reviews Genetics, 2014 - nature.com
Genome-wide association studies (GWASs) have become the focus of the statistical analysis
of complex traits in humans, successfully shedding light on several aspects of genetic …

A review of ensemble methods in bioinformatics

P Yang, Y Hwa Yang, BB Zhou… - Current …, 2010 - ingentaconnect.com
Ensemble learning is an intensively studied technique in machine learning and pattern
recognition. Recent work in computational biology has seen an increasing use of ensemble …

Regularized machine learning in the genetic prediction of complex traits

S Okser, T Pahikkala, A Airola, T Salakoski… - PLoS …, 2014 - journals.plos.org
Compared to univariate analysis of genome-wide association (GWA) studies, machine
learning–based models have been shown to provide improved means of learning such …

A novel hybrid algorithm for feature selection based on whale optimization algorithm

Y Zheng, Y Li, G Wang, Y Chen, Q Xu, J Fan… - Ieee …, 2018 - ieeexplore.ieee.org
Feature selection enhances classification accuracy by removing irrelevant and redundant
feature. Feature selection plays an important role in data mining and pattern recognition. In …

Evaluation of deep learning-based feature selection for single-cell RNA sequencing data analysis

H Huang, C Liu, MM Wagle, P Yang - Genome Biology, 2023 - Springer
Background Feature selection is an essential task in single-cell RNA-seq (scRNA-seq) data
analysis and can be critical for gene dimension reduction and downstream analyses, such …

Exploiting the ensemble paradigm for stable feature selection: a case study on high-dimensional genomic data

B Pes, N Dessì, M Angioni - Information fusion, 2017 - Elsevier
Ensemble classification is a well-established approach that involves fusing the decisions of
multiple predictive models. A similar “ensemble logic” has been recently applied to …

A review of the stability of feature selection techniques for bioinformatics data

W Awada, TM Khoshgoftaar, D Dittman… - 2012 IEEE 13th …, 2012 - ieeexplore.ieee.org
Feature selection is an important step in data mining and is used in various domains
including genetics, medicine, and bioinformatics. Choosing the important features (genes) is …

Machine learning and radiogenomics: lessons learned and future directions

J Kang, T Rancati, S Lee, JH Oh, SL Kerns… - Frontiers in …, 2018 - frontiersin.org
Due to the rapid increase in the availability of patient data, there is significant interest in
precision medicine that could facilitate the development of a personalized treatment plan for …

A novel method based on a Mask R-CNN model for processing dPCR images

Z Hu, W Fang, T Gou, W Wu, J Hu, S Zhou, Y Mu - Analytical Methods, 2019 - pubs.rsc.org
A digital polymerase chain reaction (dPCR) using fluorescence images for collecting
quantitative information needs efficient software tools to automate the image analysis …

[HTML][HTML] Predicting lifespan-extending chemical compounds for C. elegans with machine learning and biologically interpretable features

C Ribeiro, CK Farmer, JP de Magalhães… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Recently, there has been a growing interest in the development of pharmacological
interventions targeting ageing, as well as in the use of machine learning for analysing …