Sepsis, severe sepsis, and septic shock represent increasingly severe systemic
inflammatory responses to infection. Sepsis is common in the aging population, and it …

Extracellular vesicles, such as exosomes and microvesicles, are host cell-derived packages
of information that allow cell–cell communication and enable cells to rid themselves of …

Sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection,
and it probably represents a pattern of response by the immune system to injury. A hyper …

The past decade has witnessed an exponential increase in the number of publications
referring to extracellular vesicles (EVs). For many years considered to be extracellular …

The immune response to sepsis can be seen as a pattern recognition receptor-mediated
dysregulation of the immune system following pathogen invasion in which a careful balance …

The endothelium provides an essential and selective membrane barrier that regulates the
movement of water, solutes, gases, macromolecules and the cellular elements of the blood …

Coagulopathy is a severe and frequent complication in critically ill patients, for which the
pathogenesis and presentation may be variable depending on the underlying disease …

In the majority of patients with systemic inflammatory conditions, some degree of activation
of coagulation is present. Increasing evidence points to an extensive cross‐talk between …

Sepsis is a common and lethal syndrome: although outcomes have improved, mortality
remains high. No specific anti-sepsis treatments exist; as such, management of patients …

Sepsis is a serious medical condition that can lead to multi-organ failure and shock, and it is
associated with increased mortality. Acute kidney injury (AKI) is a frequent complication of …