Enhancing immunotherapy response in melanoma: myeloid-derived suppressor cells as a therapeutic target
FGO Kurt, S Lasser, I Arkhypov, J Utikal… - The Journal of …, 2023 - Am Soc Clin Investig
Despite the remarkable success of immune checkpoint inhibitors (ICIs) in melanoma
treatment, resistance to them remains a substantial clinical challenge. Myeloid-derived …
treatment, resistance to them remains a substantial clinical challenge. Myeloid-derived …
MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
Targeting histone deacetylases for cancer therapy: Trends and challenges
T Liang, F Wang, RM Elhassan, Y Cheng… - … Pharmaceutica Sinica B, 2023 - Elsevier
Dysregulation of histone deacetylases (HDACs) is closely related to tumor development and
progression. As promising anticancer targets, HDACs have gained a great deal of research …
progression. As promising anticancer targets, HDACs have gained a great deal of research …
Are inhibitors of histone deacetylase 8 (HDAC8) effective in hematological cancers especially acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) …
Abstract Histone deacetylase 8 (HDAC8) aberrantly deacetylates histone and non-histone
proteins. These include structural maintenance of chromosome 3 (SMC3) cohesin protein …
proteins. These include structural maintenance of chromosome 3 (SMC3) cohesin protein …
[HTML][HTML] Recent progress on FAK inhibitors with dual targeting capabilities for cancer treatment
X Wu, J Wang, Q Liang, R Tong, J Huang… - Biomedicine & …, 2022 - Elsevier
Focal adhesion kinase (FAK, also known as PTK2) is a tyrosine kinase that regulates
integrin and growth factor signaling pathways and is involved in the migration, proliferation …
integrin and growth factor signaling pathways and is involved in the migration, proliferation …
The key roles of the lysine acetyltransferases KAT6A and KAT6B in physiology and pathology
N Wiesel-Motiuk, YG Assaraf - Drug Resistance Updates, 2020 - Elsevier
Histone modifications and more specifically ε-lysine acylations are key epigenetic regulators
that control chromatin structure and gene transcription, thereby impacting on various …
that control chromatin structure and gene transcription, thereby impacting on various …
Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010–2020)
Y Li, S Sang, W Ren, Y Pei, Y Bian, Y Chen… - European journal of …, 2021 - Elsevier
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, which is
characterized by the primary risk factor, age. Several attempts have been made to treat AD …
characterized by the primary risk factor, age. Several attempts have been made to treat AD …
[HTML][HTML] HDAC6-dependent deacetylation of AKAP12 dictates its ubiquitination and promotes colon cancer metastasis
Y Deng, J Gao, G Xu, Y Yao, Y Sun, Y Shi, X Hao, L Niu… - Cancer letters, 2022 - Elsevier
Aberrant expression of histone deacetylase 6 (HDAC6) is greatly involved in neoplasm
metastasis, which is a leading cause of colon cancer related death. Thus, deep …
metastasis, which is a leading cause of colon cancer related death. Thus, deep …
Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells
X Tian, T Wang, H Shen, S Wang - Cytokine & Growth Factor Reviews, 2023 - Elsevier
Myeloid-derived suppressor cells (MDSCs) are important components of the tumor
microenvironment (TME), which drive the tumor immune escape by inducing …
microenvironment (TME), which drive the tumor immune escape by inducing …
Histone acetylation regulator-mediated acetylation patterns define tumor malignant pathways and tumor microenvironment in hepatocellular carcinoma
Y Xu, W Liao, Q Luo, D Yang, M Pan - Frontiers in immunology, 2022 - frontiersin.org
Background Histone acetylation modification is one of the most common epigenetic methods
used to regulate chromatin structure, DNA repair, and gene expression. Existing research …
used to regulate chromatin structure, DNA repair, and gene expression. Existing research …