Melanoma, a cancer that arises from melanocytes is one of the most unresponsive cancers
to known therapies. Several studies showed encouraging results of the efficacy of …

Cutaneous melanoma, the most aggressive type of skin cancer, remains one the most
represented forms of cancer in the United States and European countries, representing, in …

Background Gender disparity in melanoma outcome is consistently observed, suggesting
that gender is as an important prognostic factor. However, the source of this gender disparity …

Melanoma outcomes differ between men and women even when adjusted for prognostic
factors such as age, Breslow thickness, body site, ulceration, lymph node dissection, and for …

The steroid hormone receptors (SHRs) among nuclear hormone receptors (NHRs) are
steroid ligand‐dependent transcription factors that play important roles in the regulation of …

An expanding body of evidence indicates the possible role of estrane derivatives as useful
anticancer agents. The aim of this study was to describe the cytotoxic effects of 63 newly …

The folate receptor (FR) is a well-validated and common target for cancer due to its high
over-expression in many different cancer cells. Herein, we developed a new FR-targeting …

The present study illustrates the synthesis and anticancer evaluation of six, ten, twelve and
fourteen carbon chain containing cationic lipidated-estradiol hybrids. Previously, we have …

Objective This study aimed to elucidate the genetic aspects of the relationship between sex
hormones and cutaneous melanoma risk, providing valuable insights into this complex …

Apoptosis is a genetically in-built process whereby organisms remove unwanted cells.
Apoptosis can serve as a regulatory and defense mechanism in the formation of the shape …