Since the introduction of organ transplantation into medical practice, progress and optimism
have been abundant. Improvements in immunosuppressive drugs and ancillary care have …

Transplantation of organs between genetically different individuals of the same species
causes a T cell–mediated immune response that, if left unchecked, results in rejection and …

Five patients with end-stage renal disease received combined bone marrow and kidney
transplants from HLA single-haplotype mismatched living related donors, with the use of a …

The toxicity of chronic immunosuppressive agents required for organ transplant
maintenance has prompted investigators to pursue approaches to induce immune tolerance …

Many strategies have been proposed to induce tolerance to transplanted tissue in rodents;
however, few if any have shown equal efficacy when tested in nonhuman primate transplant …

Despite the ease of inhibiting immune responses by blockade of T-cell costimulation in
naive rodent models, it is difficult to suppress those responses in animals with memory cells …

Transplantation of haematopoietic stem cells—cells capable of self renewing and
reconstituting all types of blood cell—can treat numerous lethal diseases, including …

The discrepancy between organ need and organ availability represents one of the major
limitations in the field of transplantation. One possible solution to this problem is …

Six patients with renal failure due to multiple myeloma (MM) received simultaneous kidney
and bone marrow transplantation (BMT) from HLA-identical sibling donors following …

In less than 50 years the field of organ transplantation has transitioned from an experimental
concept to clinical commonplace. Notwithstanding the dramatic improvements in patient and …