Protein kinases regulate every aspect of cellular activity, whereas metabolic enzymes are
responsible for energy production and catabolic and anabolic processes. Emerging …

Highlights•Histidine phosphorylation (pHis) is reversible by specific kinases and
phosphatases.•pHis is heat and acid labile, but stable under alkaline conditions.•Stable pHis …

Histidine phosphorylation, the so-called hidden phosphoproteome, is a poorly characterized
post-translational modification of proteins,. Here we describe a role of histidine …

Histidine phosphorylation (pHis) is well studied in bacteria; however, its role in mammalian
signaling remains largely unexplored due to the lack of pHis-specific antibodies and the …

Protein phosphorylation is a reversible post-translational modification. Nine of the 20 natural
amino acids in proteins can be phosphorylated, but most of what we know about the roles of …

Protein phosphorylation is the most common type of post-translational modification in
eukaryotes. The phosphoproteome is defined as the complete set of experimentally …

Histidine phosphorylation (pHis), occurring on the histidine of substrate proteins, is a hidden
phosphoproteome that is poorly characterized in mammals. LHPP (phospholysine …

Protein N-phosphorylation plays a critical role in central metabolism and
two/multicomponent signaling of prokaryotes. However, the current enrichment methods for …

NME3 is a member of the nucleoside diphosphate kinase (NDPK) family localized on the
mitochondrial outer membrane (MOM). Here, we report a role of NME3 in hypoxia-induced …

Whereas phosphorylation of serine, threonine, and tyrosine is exceedingly well
characterized, the role of histidine phosphorylation in mammalian signaling is largely …