Acute kidney injury (AKI) and chronic kidney disease (CKD) are posing great threats to
global health within this century. Studies have suggested that estrogen and estrogen …

Glucocorticoids (GCs) are a central component of multi-drug treatment protocols against T
and B acute lymphoblastic leukemia (ALL), which are used intensively during the remission …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

The immune function of normal T cells partially depends on the maneuvering of lipid
metabolism through various stages and subsets. Interestingly, T-cell malignancies also …

Simple Summary Reduced response to glucocorticoids (GCs, such as dexamethasone,
Dex), first-line drugs employed during therapy induction, is considered a poor prognosis …

Introduction Autophagy is a cellular catabolic mechanism that helps clear damaged cellular
components and is essential for normal cellular and tissue function. The sigma-1 receptor (σ …

Among the several mechanisms accounting for endocrine resistance in breast cancer,
autophagy has emerged as an important player. Previous reports have evidenced that …

Since the role of sialome–Siglec axis has been described as a regulatory checkpoint of
immune homeostasis, the promotion of stimulatory or inhibitory Siglec-related mechanisms …

Protein homeostasis, or proteostasis, is essential for cell function and viability. Unwanted,
damaged, misfolded and aggregated proteins are degraded by the ubiquitin–proteasome …

Acute lymphoblastic leukemia (ALL) is the most common malignancy among children.
Despite the enormous progress in ALL therapy, resulting in achieving a 5-year survival rate …