There is a large unmet medical need to develop disease-modifying treatment options for
individuals with age-related degenerative diseases of the central nervous system. The …

Sigma (σ) receptors are a class of unique proteins with two subtypes: the sigma-1 (σ1)
receptor which is situated at the mitochondria-associated endoplasmic reticulum (ER) …

The use of computer-aided drug design (CADD) for the identification of lead compounds in
radiotracer development is steadily increasing. Traditional CADD methods, such as structure …

Abnormal α-synuclein (α-syn) aggregation characterizes α-synucleinopathies, including
Parkinson's disease (PD) and multiple system atrophy (MSA). However, no suitable positron …

Sigma receptors modulate nociception, offering a potential therapeutic target to treat pain,
but relatively little is known regarding the role of sigma-2 receptors (S2R) in nociception. The …

A series of σ2R compounds containing benzimidazolone and diazacycloalkane cores was
synthesized and evaluated in radioligand binding assays. Replacing the piperazine moiety …

Introduction-Several 11C-tracers have demonstrated high potential in early diagnostic PET
imaging applications of neurodegenerative diseases including Alzheimer's and Parkinson's …

Radiopharmaceuticals labeled with positron emission tomography (PET) and single-photon
emission computed tomography (SPECT) radionuclides have demonstrated high efficiency …

Chronic traumatic encephalopathy (CTE), a neurodegenerative disease associated with
repetitive mild traumatic brain injury, is characterized neuropathologically by abnormal …

The sigma-2 receptor (σ2R), recently identified as transmembrane protein 97, is expressed
in many cell types and mediates important functions in both the peripheral and central …