Oxidative stress response pathways in fungi

H Yaakoub, S Mina, A Calenda, JP Bouchara… - Cellular and Molecular …, 2022 - Springer
Fungal response to any stress is intricate, specific, and multilayered, though it employs only
a few evolutionarily conserved regulators. This comes with the assumption that one …

Molecular Mechanisms of Conidial Germination in Aspergillus spp

TJH Baltussen, J Zoll, PE Verweij… - … and Molecular Biology …, 2020 - Am Soc Microbiol
Aspergilli produce conidia for reproduction or to survive hostile conditions, and they are
highly effective in the distribution of conidia through the environment. In …

Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection

P Alves de Castro, C Figueiredo Pinzan… - Nature …, 2024 - nature.com
Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases
known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and …

Hog1 regulates stress tolerance and virulence in the emerging fungal pathogen Candida auris

AM Day, MM McNiff, A da Silva Dantas, NAR Gow… - MSphere, 2018 - Am Soc Microbiol
Candida auris has recently emerged as an important, multidrug-resistant fungal pathogen of
humans. Comparative studies indicate that despite high levels of genetic divergence, C …

The high osmolarity glycerol (HOG) pathway in fungi

H Yaakoub, NS Sanchez, L Ongay-Larios… - Critical Reviews in …, 2022 - Taylor & Francis
While fungi are widely occupying nature, many species are responsible for devastating
mycosis in humans. Such niche diversity explains how quick fungal adaptation is necessary …

The impact of bZIP Atf1ortholog global regulators in fungi

É Leiter, T Emri, K Pákozdi, L Hornok, I Pócsi - Applied Microbiology and …, 2021 - Springer
Regulation of signal transduction pathways is crucial for the maintenance of cellular
homeostasis and organismal development in fungi. Transcription factors are key elements of …

Stress-activated protein kinases in human fungal pathogens

AM Day, J Quinn - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
The ability of fungal pathogens to survive hostile environments within the host depends on
rapid and robust stress responses. Stress-activated protein kinase (SAPK) pathways are …

Analyses of the three 1-Cys Peroxiredoxins from Aspergillus fumigatus reveal that cytosolic Prx1 is central to H2O2 metabolism and virulence

MC Rocha, KF de Godoy, R Bannitz-Fernandes… - Scientific reports, 2018 - nature.com
Standing among the front defense strategies against pathogens, host phagocytic cells
release various oxidants. Therefore, pathogens have to cope with stressful conditions at the …

Fungal extracellular vesicles are involved in intraspecies intracellular communication

TA Bitencourt, O Hatanaka, AM Pessoni, MS Freitas… - MBio, 2022 - Am Soc Microbiol
Fungal infections are associated with high mortality rates in humans. The risk of fungal
diseases creates the urgent need to broaden the knowledge base regarding their …

Mitogen-activated protein kinase cross-talk interaction modulates the production of melanins in Aspergillus fumigatus

AO Manfiolli, FS Siqueira, TF Dos Reis, P Van Dijck… - mbio, 2019 - Am Soc Microbiol
The pathogenic fungus Aspergillus fumigatus is able to adapt to extremely variable
environmental conditions. The A. fumigatus genome contains four genes coding for mitogen …