Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …

For tuberculosis to be eradicated, the transmission of Multi-Drug-Resistant and eXtensively
Drug Resistant strains of Mycobacterium tuberculosis (MDR and XDR-TB) must be …

At present, the successful transmission of drug‐resistant Mycobacterium tuberculosis,
including multidrug‐resistant (MDR) and extensively drug‐resistant (XDR) strains, in human …

Life-threatening bacterial infections have been managed by antibiotics for years and have
significantly improved the wellbeing and lifetime of humans. However, bacteria have always …

Abstract Purpose of Review Computational and mathematical modeling have become a
critical part of understanding in-host infectious disease dynamics and predicting effective …

Background Antibiotics remain the cornerstone of modern medicine. Yet there exists an
inherent dilemma in their use: we are able to prevent harm by administering antibiotic …

In this review, we describe diagnostic strategies specifically for HIV and TB co-infected
individuals. Molecular diagnostics in particular within the past 5 years have revolutionized …

Whole genome sequencing (WGS) can elucidate Mycobacterium tuberculosis (Mtb)
transmission patterns but more data is needed to guide its use in high-burden settings. In a …

Compensatory mutations have been suggested to promote multidrug-resistant tuberculosis
(MDR-TB) transmission, but their role in facilitating the recent transmission of MDR-TB is …

BACKGROUND: Differences in the prevalence of latent tuberculous infection (LTBI) and
tuberculosis (TB) disease among contacts of patients with multidrug-resistant TB (MDR-TB) …