New biomarkers are being evaluated for their ability to advance the management of patients
with heart failure. Despite a large pool of interesting candidate biomarkers, besides …

Galectin-3 (Gal-3) is a β-galactoside-binding protein belonging to the lectin family with
pleiotropic regulatory activities and several physiological cellular functions, such as cellular …

Aims To investigate the effects of spironolactone on fibrosis and cardiac function in people at
increased risk of developing heart failure. Methods and results Randomized, open-label …

This article provides an update regarding the most recent published literature on galectin-3
as a biomarker in heart failure (HF) and gives an outlook toward its use as a biotarget. 1 In …

Cardiac remodelling refers to changes in left ventricular structure and function over time,
with a progressive deterioration that may lead to heart failure (HF) development (adverse …

Rationale & Objective Inflammation, cardiac remodeling, and fibrosis may explain in part the
excess risk for cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) …

The use of circulating biomarkers for heart failure (HF) is engrained in contemporary
cardiovascular practice and provides objective information about various pathophysiological …

Galectin-3 plays a prominent role in chronic inflammation and has been implicated in the
development of many disease conditions, including heart disease. Galectin-3, a regulatory …

Fibrosis, stiffening and scarring of an organ/tissue due to genetic abnormalities,
environmental factors, infection, and/or injury, is responsible for> 40% of all deaths in the …

Intermediate filament (IF) proteins are critical regulators in health and disease. The
discovery of hundreds of mutations in IF genes and posttranslational modifications has been …