The quality of fetal growth and development predicts the risk for a range of
noncommunicable, chronic illnesses. These observations form the basis of the …

In this volume of the IJE, Gao and colleagues explore the causal effect of adiposity on
several cancers using twosample Mendelian randomization (MR), and find some evidence …

Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …

Motivation LD score regression is a reliable and efficient method of using genome-wide
association study (GWAS) summary-level results data to estimate the SNP heritability of …

Identifying genetic correlations between complex traits and diseases can provide useful
etiological insights and help prioritize likely causal relationships. The major challenges …

Mendelian randomisation (MR) estimates causal effects of modifiable phenotypes on an
outcome by using genetic variants as instrumental variables, but its validity relies on the …

Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in
observational studies is reproducibly associated with future risk of adult metabolic diseases …

Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes …

Single nucleotide polymorphisms (SNPs) that cluster in the first intron of fat mass and
obesity associated (FTO) gene are associated obesity traits in genome-wide association …

Chronic sleep disturbances, associated with cardiometabolic diseases, psychiatric disorders
and all-cause mortality,, affect 25–30% of adults worldwide. Although environmental factors …