Given the complexities of the mammalian CNS, its regeneration is viewed as the holy grail of
regenerative medicine. Extraordinary efforts have been made to understand developmental …

Mitotic activity persists in various regions of the adult mammal CNS. While evidences of
neurogenesis appeared, many studies focused on the features of the adult stem cells from …

During aging and in the progression of Alzheimer's disease (AD), synaptic plasticity and
neuronal integrity are disturbed. In addition to the alterations in plasticity in mature neurons …

Although stem cell-based treatments for stroke and other neurodegenerative diseases have
advanced rapidly, there are still few clinical treatments available. In this study, rats receiving …

Bone morphogenetic proteins (BMPs) are phylogenetically conserved signaling molecules
that belong to the transforming growth factor (TGF)-β superfamily, and are involved in the …

Mesencephalic astrocyte‐derived neurotrophic factor (MANF), also known as arginine‐rich,
mutated in early stage of tumors (ARMET), is a secreted protein that reduces endoplasmic …

Background and Purpose—The migratory efficiency of mesenchymal stem cells (MSC)
toward cerebral infarct after transplantation is limited. Valproate (VPA) and lithium enhance …

This review addresses the role of serum insulin-like growth factor 1 (IGF1) as one
mechanism of adult neural plasticity, specifically, its regulation of hippocampal …

Background Efficient and topical delivery of drugs is essential for maximized efficacy and
minimized toxicity. In this study, we aimed to design an exosome-based drug delivery …

Stromal cell-derived factor (SDF)-1α is involved in the trafficking of hematopoietic stem cells
from bone marrow to peripheral blood, and its expression is increased in the penumbra of …