Surgical intensive care unit (ICU) stay of longer than 10 days is often described by the
experienced intensivist as a “complicated clinical course” and is frequently attributed to …

Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

Sepsis is a serious medical condition characterized by dysregulated systemic inflammatory
responses followed by immunosuppression. To study the pathophysiology of sepsis, diverse …

Sepsis is the leading cause of death in critically ill patients in the United States. Yet the
individual host response to septicemia is variable, depending on the patient's immune …

Sepsis remains a common, serious, and heterogeneous clinical entity that is difficult to
define adequately. Despite its importance as a public health problem, efforts to develop and …

Sepsis and sepsis syndrome are leading causes of mortality throughout the world. It is
widely held that sepsis represents a dysregulated innate immune response to an offending …

Host innate responses to bacterial infections are primarily mediated by neutrophils and
monocytes/macrophages,. These cells express pattern recognition receptors (PRRs) that …

Physiological anti-inflammatory mechanisms can potentially be exploited for the treatment of
inflammatory disorders. Here we report that the neurotransmitter acetylcholine inhibits …

Sepsis is a state of disrupted inflammatory homeostasis that is often initiated by infection.
The development and progression of sepsis is multi-factorial, and affects the cardiovascular …

Sepsis is characterized by a severe inflammatory response to infection, and its
complications, including acute kidney injury, can be fatal. Animal models that correctly mimic …