Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus

T Nuutinen - European journal of medicinal chemistry, 2018 - Elsevier
Cannabaceae plants Cannabis sativa L. and Humulus lupulus L. are rich in terpenes–both
are typically comprised of terpenes as up to 3–5% of the dry-mass of the female …

Emerging antifungal targets and strategies

M Ivanov, A Ćirić, D Stojković - International Journal of Molecular …, 2022 - mdpi.com
Despite abundant research in the field of antifungal drug discovery, fungal infections remain
a significant healthcare burden. There is an emerging need for the development of novel …

Antifungal drugs: New insights in research & development

AM Nicola, P Albuquerque, HC Paes… - Pharmacology & …, 2019 - Elsevier
The need for better antifungal therapy is commonly accepted in view of the high mortality
rates associated with systemic infections, the low number of available antifungal classes …

Pharmacological and biological effects of alpha-bisabolol: An updated review of the molecular mechanisms

E Ramazani, M Akaberi, SA Emami… - Life Sciences, 2022 - Elsevier
Abstract Alpha-bisabolol (α-bisabolol), an unsaturated monocyclic sesquiterpene alcohol, is
known as one of the “most-used herbal constituents” in the world. Various therapeutic and …

Health benefits, pharmacological effects, molecular mechanisms, and therapeutic potential of α-bisabolol

LB Eddin, NK Jha, SN Goyal, YO Agrawal… - Nutrients, 2022 - mdpi.com
α-Bisabolol is one of the important monocyclic sesquiterpenes, derived naturally from
essential oils of many edible and ornamental plants. It was first obtained from Matricaria …

Update on fungal lipid biosynthesis inhibitors as antifungal agents

M Vishwakarma, T Haider, V Soni - Microbiological Research, 2024 - Elsevier
Fungal diseases today represent a world-wide problem. Poor hygiene and decreased
immunity are the main reasons behind the manifestation of this disease. After COVID-19, an …

Antifungal Activity of Plant Waste Extracts against Phytopathogenic Fungi: Allium sativum Peels Extract as a Promising Product Targeting the Fungal Plasma …

A Teixeira, E Sánchez-Hernández, J Noversa, A Cunha… - Horticulturae, 2023 - mdpi.com
The harmful effect of synthetic fungicides on the environment and the development of
resistance by fungi raises concerns about their security and future efficacy. In this work, we …

Characterization of an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase to treat Candida albicans infections

X Jin, X Hou, X Wang, M Zhang, J Chen, M Song… - Cell Chemical …, 2023 - cell.com
Filamentation is an important virulence factor of the pathogenic fungus Candida albicans.
The abolition of Candida albicans hyphal formation by disrupting sterol synthesis is an …

Phytochemical composition, bioactive properties, and toxicological profile of Tetrapleura tetraptera

TG Anyamele, PN Onwuegbuchu, EA Ugbogu… - Bioorganic Chemistry, 2023 - Elsevier
The use of medicinal plants has gained renewed wide popularity in Africa, Asia, and most
parts of the world because of the decreasing efficacy of synthetic drugs. Thus, natural …

Erg6p is essential for antifungal drug resistance, plasma membrane properties and cell wall integrity in Candida glabrata

D Elias, N Toth Hervay, J Jacko… - FEMS Yeast …, 2022 - academic.oup.com
ERG6 gene encodes C-24 methyltransferase, one of the specific enzymes that differ in
mammalian and yeast sterol biosynthesis. To explore the function of Cg Erg6p in the yeast …