Numerous studies attest to essential roles for Eph receptors and their ephrin ligands in
controlling cell positioning and tissue patterning during normal and oncogenic development …

The non-catalytic region of tyrosine kinase (Nck) family of adaptors, consisting of Nck1 and
Nck2, contributes to selectivity and specificity in the flow of cellular information by recruiting …

Neuronal network formation in the developing nervous system is dependent on the accurate
navigation of nerve cell axons and dendrites, which is controlled by attractive and repulsive …

Protein–protein interactions (PPIs) between modular binding domains and their target
peptide motifs are thought to largely depend on the intrinsic binding specificities of the …

Ephrins and Eph receptors are involved in the establishment of vertebrate tissue
boundaries. The complexity of the system is puzzling, however in many instances, tissues …

EPH receptors (EPHRs) constitute the largest family among receptor tyrosine kinases in
humans. They are mainly involved in short-range cell-cell communication events that …

The intracellular signaling targets used by mammalian axon guidance receptors to organize
the nervous system in vivo are unclear. The Nck1 and Nck2 SH2/SH3 adaptors (collectively …

Glucagon hypersecretion from pancreatic islet α-cells exacerbates hyperglycemia in type 1
diabetes (T1D) and type 2 diabetes. Still, the underlying mechanistic pathways that regulate …

The Eph family of receptors is the largest family of receptor tyrosine kinases, but it remains
poorly studied in lung cancer. We aimed to systematically explore the human Eph receptors …

Phosphotyrosine (pTyr) signaling has evolved into a key cell-to-cell communication system.
Activated receptor tyrosine kinases (RTKs) initiate several pTyr-dependent signaling …