Barometric pressure falls with increasing altitude and consequently there is a reduction in
the partial pressure of oxygen resulting in a hypoxic challenge to any individual ascending …

High-altitude pulmonary edema (HAPE) is an uncommon form of pulmonary edema that
occurs in healthy individuals within a few days of arrival at altitudes above 2,500–3,000 m …

Background High altitude illness (HAI) is a term used to describe a group of cerebral and
pulmonary syndromes that can occur during travel to elevations above 2500 metres (8200 …

Exercise-induced intrapulmonary arteriovenous shunting, as detected by saline contrast
echocardiography, has been demonstrated in healthy humans. We have previously …

As the first step in the oxygen-transport chain, the lung has a critical task: optimizing the
exchange of respiratory gases to maintain delivery of oxygen and the elimination of carbon …

Carbonic anhydrase (CA) inhibitors, particularly acetazolamide, have been used at high
altitude for decades to prevent or reduce acute mountain sickness (AMS), a syndrome of …

Hypoxic environments at high altitudes influence the long-term non-altitude health of
residents, by inducing changes in metabolism and the mitochondria, severe lung injury, and …

Acetazolamide prevents acute mountain sickness (AMS) by inhibition of carbonic
anhydrase. Since it also reduces acute hypoxic pulmonary vasoconstriction (HPV), it may …

Carbonic anhydrase (CA) and its inhibitors are relevant to many physiological processes
and diseases. The enzyme is differentially expressed throughout the body, in concentration …

Adults with a history of very preterm birth (< 32 wk gestational age; PRET) have reduced
lung function and significantly lower lung diffusion capacity for carbon monoxide (DLCO) …