Gut barrier disruption and chronic disease

J Martel, SH Chang, YF Ko, TL Hwang… - Trends in Endocrinology …, 2022 - cell.com
The intestinal barrier protects the host against gut microbes, food antigens, and toxins
present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic …

[HTML][HTML] Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?

S Deleu, K Machiels, J Raes, K Verbeke, S Vermeire - EBioMedicine, 2021 - thelancet.com
The gut microbiome and the intestinal immune system are driving contributors to
inflammatory bowel diseases (IBD). Both have an important signalling factor in common …

Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome

Y Kawano, M Edwards, Y Huang, AM Bilate, LP Araujo… - Cell, 2022 - cell.com
How intestinal microbes regulate metabolic syndrome is incompletely understood. We show
that intestinal microbiota protects against development of obesity, metabolic syndrome, and …

The metabolic nature of inflammatory bowel diseases

TE Adolph, M Meyer, J Schwärzler, L Mayr… - Nature Reviews …, 2022 - nature.com
Crohn's disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …

[HTML][HTML] Excessive intake of sugar: An accomplice of inflammation

X Ma, F Nan, H Liang, P Shu, X Fan, X Song… - Frontiers in …, 2022 - frontiersin.org
High sugar intake has long been recognized as a potential environmental risk factor for
increased incidence of many non-communicable diseases, including obesity, cardiovascular …

Leveraging diet to engineer the gut microbiome

M Wolter, ET Grant, M Boudaud, A Steimle… - Nature reviews …, 2021 - nature.com
Autoimmune diseases, including inflammatory bowel disease, multiple sclerosis and
rheumatoid arthritis, have distinct clinical presentations but share underlying patterns of gut …

[HTML][HTML] Microbiome-based interventions to modulate gut ecology and the immune system

TCA Hitch, LJ Hall, SK Walsh, GE Leventhal, E Slack… - Mucosal …, 2022 - Elsevier
The gut microbiome lies at the intersection between the environment and the host, with the
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …

Diet fuelling inflammatory bowel diseases: preclinical and clinical concepts

TE Adolph, J Zhang - Gut, 2022 - gut.bmj.com
The diet and gut microbiota have been extensively interrogated as a fuel for gut
inflammation in inflammatory bowel diseases (IBDs) in the last few years. Here, we review …

[HTML][HTML] The role of diet in shaping human gut microbiota

E Rinninella, E Tohumcu, P Raoul, M Fiorani… - Best Practice & …, 2023 - Elsevier
Gut microbiota plays a fundamental role within human health, and exerts key functions
within the human body. Diet is one of the most powerful modulators of gut microbiota …

[HTML][HTML] Dietary patterns and gut microbiota changes in inflammatory bowel disease: current insights and future challenges

J Yan, L Wang, Y Gu, H Hou, T Liu, Y Ding, H Cao - Nutrients, 2022 - mdpi.com
Inflammatory bowel disease (IBD) is a result of a complex interplay between genes, host
immune response, gut microbiota, and environmental factors. As one of the crucial …