Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …

This brief overview of endocytic trafficking is written in honor of Renate Fuchs, who retires
this year. In the mid-1980s, Renate pioneered studies on the ion-conducting properties of …

Transient “kiss and run” interactions between endosomes containing iron-bound transferrin
(Tf) and mitochondria have been shown to facilitate direct iron transfer in erythroid cells. In …

The ε4 allele of apolipoprotein E (APOE4) is a genetic risk factor for many diseases,
including late-onset Alzheimer's disease (AD). We investigate the cellular consequences of …

Programmed death-ligand 1 (PD-L1), a critical immune checkpoint ligand, is a
transmembrane protein synthesized in the endoplasmic reticulum of tumor cells and …

Cholera toxin B-subunit (CTxB) has emerged as one of the most widely utilized tools in
membrane biology and biophysics. CTxB is a homopentameric stable protein that binds …

Exploring the cell biology of hepatocytes in vitro could be a powerful strategy to dissect the
molecular mechanisms underlying the structure and function of the liver in vivo. However …

Endocytosis in mammalian cells is a fundamental cellular machinery that regulates vital
physiological processes, such as the absorption of metabolites, release of neurotransmitters …

Abstract USP6NL, also named RN-tre, is a GTPase-activating protein involved in control of
endocytosis and signal transduction. Here we report that USP6NL is overexpressed in …

Secretory pore-forming proteins (PFPs) have been identified in organisms from all kingdoms
of life. Our studies with the toad species Bombina maxima found an interaction network …