Purpose: To retain cell viability, mammalian cells can increase damage repair in response to
excessive radiation-induced injury. The adaptive response to small radiation doses is an …

DNA double-strand breaks (DSB) are considered to be critical primary lesions in the
formation of chromosomal aberrations. DSB may be induced by exogenous agents, such as …

Chromosomal aberrations (CA) are the microscopically visible part of a wide spectrum of
DNA changes generated by different repair mechanisms of DNA double strand breaks …

DNA is under constant assault from genotoxic agents which creates different kinds of DNA
damage. The precise replication of the genome and the continuous surveillance of its …

Genomic DNA in eukaryotic cells is basically divided into chromosomes, each consisting of
a single huge nucleosomal fiber. It is now clear that chromatin structure and dynamics play a …

Translocations are the most frequent chromosome structural aberration in the human
population, yet little is known about their aetiology. Here, factors that might influence the …

The fact that eukaryotic DNA is packed into chromatin constitutes a physical barrier to
enzymes and regulatory factors to reach the DNA molecule for replication, transcription …

DNA double strand breaks (DSBs) are ultimate lesions for the formation of chromosomal
aberrations (CAs). The formation of CAs is dependent on many factors; some of these are …

Chromosomal rearrangements occur as a consequence of the erroneous repair of DNA
double-stranded breaks, and often underlie disease. The recurrent detection of specific …

Peripheral lymphocytes were exposed to 4 Gy X-rays and aberrations were analysed in
human chromosome 5 using high-resolution multicolour banding fluorescence in-situ …