After Edward Jenner established human vaccination over 200 years ago, attenuated
poxviruses became key players to contain the deadliest virus of its own family: Variola virus …

Modified vaccinia virus Ankara (MVA) is the leading poxvirus vector for development of
vaccines against diverse infectious diseases. This distinction is based on high expression of …

Sustained activation of the Raf/MEK/extracellular signal-regulated kinase (ERK) pathway in
infected cells has been shown to be crucial for full replication efficiency of orthopoxviruses in …

Monkeypox virus (MPXV) is an emerging pathogen from Africa that causes disease similar to
smallpox. Two clades with different geographic distributions and virulence have been …

Modified vaccinia virus Ankara (MVA), a widely used vaccine vector for expression of genes
of unrelated pathogens, is safe, immunogenic, and can incorporate large amounts of added …

The precise immune components required for protection against a respiratory Orthopoxvirus
infection, such as human smallpox or monkeypox, remain to be fully identified. In this study …

The selection of a cell substrate is a critical step for the development and manufacturing of a
viral vaccine candidate. Several parameters such as cell susceptibility and permissiveness …

Viruses are used as expression vectors for protein synthesis, immunology research,
vaccines, and therapeutics. Advantages of poxvirus vectors include the accommodation of …

Oncolytic virus therapy has recently been recognized as a promising new therapeutic
approach for cancer treatment. In this study, we are proposing for the first time to evaluate …

Vaccinia virus (VACV) genes are characterized as either essential or non-essential for
growth in culture. It seems intuitively obvious that if a gene can be deleted without imparting …