The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates

NI Mazur, D Higgins, MC Nunes, JA Melero… - The Lancet Infectious …, 2018 - thelancet.com
The global burden of disease caused by respiratory syncytial virus (RSV) is increasingly
recognised, not only in infants, but also in older adults (aged≥ 65 years). Advances in …

Respiratory syncytial virus vaccines: a review of the candidates and the approved vaccines

X Topalidou, AM Kalergis, G Papazisis - Pathogens, 2023 - mdpi.com
Respiratory syncytial virus (RSV) is responsible for a significant proportion of global
morbidity and mortality affecting young children and older adults. In the aftermath of formalin …

The BCG vaccine for COVID-19: first verdict and future directions

M Gonzalez-Perez, R Sanchez-Tarjuelo… - Frontiers in …, 2021 - frontiersin.org
Despite of the rapid development of the vaccines against the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), it will take several months to have enough doses …

Could BCG vaccination induce protective trained immunity for SARS-CoV-2?

C Covián, A Retamal-Díaz, SM Bueno… - Frontiers in …, 2020 - frontiersin.org
Trained immunity is a type of non-specific memory-like immune response induced by some
pathogens and vaccines, such as BCG, which can confer antigen-independent protection …

T cell–mediated host immune defenses in the lung

K Chen, JK Kolls - Annual review of immunology, 2013 - annualreviews.org
Evidence has increasingly shown that the lungs are a major site of immune regulation. A
robust and highly regulated immune response in the lung protects the host from pathogen …

Respiratory syncytial virus vaccine development

JL Hurwitz - Expert review of vaccines, 2011 - Taylor & Francis
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract viral disease
in infants and young children. Presently, there are no explicit recommendations for RSV …

Current GMP standards for the production of vaccines and antibodies: An overview

CE Covarrubias, TA Rivera, CA Soto, T Deeks… - Frontiers in Public …, 2022 - frontiersin.org
The manufacture of pharmaceutical products made under good manufacturing practices
(GMP) must comply with the guidelines of national regulatory bodies based on international …

Safety and immunogenicity evaluation of recombinant BCG vaccine against respiratory syncytial virus in a randomized, double-blind, placebo-controlled phase I …

K Abarca, E Rey-Jurado, N Munoz-Durango… - …, 2020 - thelancet.com
Background Respiratory syncytial virus (RSV) is responsible for most respiratory tract
infections and hospitalizations in infants and represents a significant economic burden for …

All Eyes on the Prefusion-Stabilized F Construct, but Are We Missing the Potential of Alternative Targets for Respiratory Syncytial Virus Vaccine Design?

S Schaerlaekens, L Jacobs, K Stobbelaar, P Cos… - Vaccines, 2024 - mdpi.com
Respiratory Syncytial Virus (RSV) poses a significant global health concern as a major
cause of lower respiratory tract infections (LRTIs). Over the last few years, substantial efforts …

Impaired learning resulting from respiratory syncytial virus infection

JA Espinoza, K Bohmwald… - Proceedings of the …, 2013 - National Acad Sciences
Respiratory syncytial virus (RSV) is the major cause of respiratory illness in infants
worldwide. Neurologic alterations, such as seizures and ataxia, have been associated with …