Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …

The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …

The BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2,
BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional …

Aurora kinase A (AURKA) has emerged as a drug target for glioblastoma (GBM). However,
resistance to therapy remains a critical issue. By integration of transcriptome, chromatin …

Summary Bromodomain-containing protein 4 (BRD4) is a cancer therapeutic target in
ongoing clinical trials disrupting primarily BRD4-regulated transcription programs. The role …

The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …

Characterized by intracellular lipid droplet accumulation, clear cell renal cell carcinoma
(ccRCC) is resistant to cytotoxic chemotherapy and is a lethal disease. Through an unbiased …

The mammalian bromodomain and extra-terminal domain (BET) family of proteins consists
of four conserved members (Brd2, Brd3, Brd4, and Brdt) that regulate numerous cancer …

The majority of patients with neuroblastoma due to MYCN oncogene amplification and
consequent N-Myc oncoprotein over-expression die of the disease. Here our analyses of …

To achieve the very high oncoprotein levels required to drive the malignant state cancer
cells utilise the ubiquitin proteasome system to upregulate transcription factor levels. Here …